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Alterations of the glycosylation machinery are a common event in cancer that leads to the synthesis of aberrant glycan structures by tumor cells. Extracellular vesicles (EVs) play a modulator role in cancer communication and progression, and interestingly, several tumor-associated glycans have alrea...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035650 | Pride
The clinical performance of trastuzumab in the treatment of ErbB2-positive gastric cancer is severely hampered by the emergence of molecular resistance. The glycosylation landscape of ErbB2’s extracellular domain, and the molecular mechanisms through which it tunes gastric cell malignancy, including...
ORGANISM(S): Homo sapiens (Human) 
2021-05-11 | PXD017609 | Pride
LC-MS/MS glycoproteomic analysis of EGFR N-glycosylation profile. EGFR immunoprecipitated from colorectal cancer cell lines SW48 (wild-type and ST6Gal1 overexpression) and Caco-2 (wild-type and ST6Gal1 knock-out)
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD017914 | Pride
This group is focusing on the molecular mechanisms of the biosynthesis of glycoconjugates and carbohydrate ligands important in the process of gastric carcinogenesis and on gastric carcinoma progression and metastasis. The adhesion of H. pylori to epithelial cells induces a variety of modifications,...
ORGANISM(S): Homo sapiens 
Glycomic analysis of total N-glycan species released from ErbB2 isolated from WT and ST6GAL1 K.O. ErbB2-positive gastric cancer cells (NCI-N87)
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-11 | MSV000084943 | MassIVE
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