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ProteomicsModulation of ST6Gal1 in Prostate Cancer Cells
Proteomics analyses using LC-MS/MS was performed on wild-type and ST6Gal1 overexpressing DU145 prostate cancer cells. Total cell lysate and secreted proteins from both were analyzed.
ORGANISM(S): Homo sapiens (Human) 
2023-11-06 | PXD041316 | Pride
Glycosylation St6gal1 Cancer Cell line 
ProteomicsST6GAL1-driven sialyl-linkage switching in polarizing macrophages promotes formation of α2,6-sialylated nanotubes in anti-inflammatory cells
Tumor-associated macrophages (TAMs) form functionally diverse populations of innate immune cells in the tumor microenvironment. While the pro- and anti-inflammatory TAMs are recognized to shape inflammation and impact disease progression in cancer, the molecular and cellular perturbations of the gly...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD057634 | Pride
St6gal1 Macrophage Sialic acids Nanotubes Sialylation Colorectal cancer. 
TranscriptomicsTranscription profiling of mouse tumors arising in wild-type or St6gal1 null littermates
Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer. A classic but unexplained example is enhanced α2-6-sialylation on N-glycans, resulting from over-expression of ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9447 | biostudies-arrayexpress
GenomicsRNAseq of ST6GAL1-wild type and ST6GAL1-knock out cells of MDA-MB-231 cells.
RNAseq of ST6GAL1-wild type and ST6GAL1-knock out cells of MDA-MB-231 cells.
PRJNA728106 | ENA
GenomicsHuman B-cell precursor acute lymphoblastic leukemia cells overexpressing ST6Gal1
Human B-cell precursor acute lymphoblastic leukemia cells overexpressing ST6Gal1
PRJNA770077 | ENA
GenomicsST6Gal1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression
ST6Gal1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression
PRJNA979231 | ENA
GenomicsIdentifying ST6GAL1 as a novel factor for human dermal fibroblast photoaging
Identifying ST6GAL1 as a novel factor for human dermal fibroblast photoaging
PRJNA1459316 | ENA
GenomicsST6Gal1 sialyltransferase promotes pancreatic ductal adenocarcinoma by facilitating acinar to ductal metaplasia
ST6Gal1 sialyltransferase promotes pancreatic ductal adenocarcinoma by facilitating acinar to ductal metaplasia
PRJNA716991 | ENA
TranscriptomicsHuman B-cell precursor acute lymphoblastic leukemia cells overexpressing ST6Gal1
Normal early human B-cells development from lymphoid progenitors in the bone marrow is dependent upon instructions from elements in that microenvironment which include stromal cells as well as extracellular matrix and factors secreted by these cells. Glycosylation is thought to play a key role in su...
ORGANISM(S): Homo sapiens 
2022-04-06 | GSE185611 | GEO
TranscriptomicsIdentifying ST6GAL1 as a novel factor for human dermal fibroblast photoaging
Due to increasing global UV exposure from environmental changes and lifestyle factors, understanding the molecular mechanisms of photoaging is critical in dermatological research. This study addresses the underexplored role of glycosylation in dermal fibroblast photoaging by establishing an in vitro...
ORGANISM(S): Homo sapiens 
2026-09-02 | GSE329475 | GEO
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