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ProteomicsTherapeutic potential of allosteric HECT E3 ligase inhibition
Supplemental proteomics data Abstract: Inhibition of ubiquitin E3-ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches to inhibitor identification. In a large unbiased physical screen, we discovered inhibitors that bind a cryptic cavi...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD051134 | Pride
Drug discovery E6ap Pulmonary arterial hypertension Small molecule Ubiquitin e3-ligase Vascular remodeling Hect Allosteric inhibition Smurf1 Glycine hinge 
ProteomicsComplement factor B is critical for sub-RPE deposit formation in the Efemp1 R345W mutant mouse model with features of age-related macular degeneration
This dataset represent supplemental data for publication submitted to Human Molecular Genetics in 2022. Briefly, Efemp1 R345W is a protein misfolding-prone mutation in humans causing Doyne honeycomb retinal dystrophy/Mallatia Leventinese (DHRD/ML), a disease sharing similar clinical pathology with ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035772 | Pride
Tmt proteomics Mouse efemp1 model Age-related macular degeneration 
ProteomicsQuantitative Proteomics of the Cancer Cell Line Encyclopedia
The Cancer Cell Line Encyclopedia (CCLE) is a collaborative effort to generate steady-state large-scale profiling across a collection of nearly a thousand cancer cell lines. Multiple generations of this effort have resulted in a collection of many data types such as RNA expression, mutation annotati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-27 | MSV000085836 | MassIVE
ProteomicsHighly multiplexed quantitative phosphosite assay for biology and preclinical studies
Reliable methods to quantify dynamic signaling changes across diverse pathways are needed to better understand the effects of disease and drug treatment in cells and tissues but are presently lacking. Here we present SigPath, a targeted mass spectrometry (MS) assay that measures 284 phosphosites in ...
ORGANISM(S): Homo Sapiens 
2021-10-08 | PXD026939 | panorama
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