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ProteomicsTherapeutic potential of allosteric HECT E3 ligase inhibition
Supplemental proteomics data Abstract: Inhibition of ubiquitin E3-ligases is therapeutically attractive; however, the absence of an active-site pocket impedes computational approaches to inhibitor identification. In a large unbiased physical screen, we discovered inhibitors that bind a cryptic cavi...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD051134 | Pride
Drug discovery E6ap Pulmonary arterial hypertension Small molecule Ubiquitin e3-ligase Vascular remodeling Hect Allosteric inhibition Smurf1 Glycine hinge 
ProteomicsComplement factor B is critical for sub-RPE deposit formation in the Efemp1 R345W mutant mouse model with features of age-related macular degeneration
This dataset represent supplemental data for publication submitted to Human Molecular Genetics in 2022. Briefly, Efemp1 R345W is a protein misfolding-prone mutation in humans causing Doyne honeycomb retinal dystrophy/Mallatia Leventinese (DHRD/ML), a disease sharing similar clinical pathology with ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035772 | Pride
Tmt proteomics Mouse efemp1 model Age-related macular degeneration 
ProteomicsQuantitative Proteomics of the Cancer Cell Line Encyclopedia
The Cancer Cell Line Encyclopedia (CCLE) is a collaborative effort to generate steady-state large-scale profiling across a collection of nearly a thousand cancer cell lines. Multiple generations of this effort have resulted in a collection of many data types such as RNA expression, mutation annotati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-27 | MSV000085836 | MassIVE
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