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TranscriptomicsGermline genomic variations associated with childhood acute lymphoblastic leukemia
We identified germline single nucleotide polymorphisms (SNPs) associated with childhood acute lymphoblastic leukemia (ALL) and its subtypes. Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed (P<1x10-5) between a pediatric...
ORGANISM(S): Homo sapiens 
2009-08-16 | E-GEOD-17195 | biostudies-arrayexpress
UnknownPostinduction dexamethasone and individualized dosing of Escherichia Coli L-asparaginase each improve outcome of children and adolescents with newly diagnosed acute lymphoblastic leukemia: results from a randomized study--Dana-Farber Cancer Institute ALL Consortium Protocol 00-01.
Not available
S-EPMC3595424 | biostudies-literature
UnknownHyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group.
Not available
S-EPMC3927733 | biostudies-literature
UnknownMercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1.
Not available
S-EPMC5455766 | biostudies-literature
UnknownNeurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia Randomly Assigned to Different Methotrexate and Corticosteroid Treatment Strategies: A Report From the Children's Oncology Group.
Not available
S-EPMC5549456 | biostudies-literature
UnknownTP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.
Not available
S-EPMC5815403 | biostudies-literature
UnknownClinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.
Not available
S-EPMC4962704 | biostudies-literature
GenomicSLCO1B1 Variants and Methotrexate Clearance

Methotrexate plasma concentration is related to its clinical effects. To identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia (ALL), we performed a genome-wide analysis (GWAS) of 500,568 ge...

phs000426 | dbGaP
UnknownChildhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.
Not available
S-EPMC4567699 | biostudies-literature
GenomicsMethotrexate Clearance GWAS in Acute Lymphoblastic Leukemia (ALL) Patients

We estimated the plasma clearance of methotrexate from 1279 acute lymphoblastic leukemia (ALL) patients treated on the Children Oncology Group 9904 and 9905 trials (http://clinicaltrials.gov/show/NCT00005585 and

phs000637.v1.p1 | EGA
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