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ProteomicsSystems Signature Reveals Unique Remission-path of Diabetes Generated by Gastric Bypass Surgery
Gastric bypass surgery (GBP) emerging as a powerful tool for treatment of obesity has been applied for remission of diabetes. However, the GBP global molecular effects on diabetes remission independent of weight loss remain largely unknown. We profiled plasma metabolites and proteins of 10 normoglyc...
ORGANISM(S): Homo sapiens (Human) 
2017-12-13 | PXD008071 | Pride
Network Gastric bypass Diabetes Systems signature 
TranscriptomicsSingle cell RNA and CITE sequencing of cells from synovial tissue biopsies of healthy donors, and Rheumatoid Arthritis (RA) patients with active disease or sustained clinical remission
The dataset includes the raw FASTQ files generated from the 10x Genomics Single Cell 3’ v3.1 experiments. For samples processed with TotalSeq Hashtag reagents, the corresponding hashtag oligonucleotide and condition annotations are provided as separate .csv files. The processed matrices contain filt...
ORGANISM(S): Homo sapiens 
2024-12-06 | E-MTAB-14213 | biostudies-arrayexpress
ProteomicsTowards a proteomic plasma biomarker panel for diagnosing vasculitis remission
Active anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) requires intensive immunosuppressive therapy, but continued treatment after remission is achieved can cause serious harm. Reliable biomarkers to confirm remission are lacking, forcing clinicians to prolong cost-intens...
ORGANISM(S): Homo sapiens (Human) 
2026-06-05 | PXD079232 | Pride
Machine learning Vasculitis Multi-biomarker panel Plasma proteomics Anti-neutrophil cytoplasmic autoantibodies 
TranscriptomicsExpression data from intestinal mucosa of patients with UC
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with preiods of active disease followed by remission. We performed a whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, as well as non-inflammatory controls. Ulcera...
ORGANISM(S): Homo sapiens 
2012-11-09 | E-GEOD-38713 | biostudies-arrayexpress
GenomicsTranscriptional signatures that define Ulcerative Colitis in remission
Transcriptional signatures that define Ulcerative Colitis in remission
PRJNA528490 | ENA
ProteomicsIntegrative Plasma Proteomics and Myeloid-Interferon Profiling Reveal an AI-Validated Vascular-Endothelial Stress Signature Distinguishing SLE Flare from Remission in an Indian Cohort A Discovery – Phase Study
Background: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder characterized by unpredictable flares and variable clinical quiescence. Despite validated clinical indices like the British Isles Lupus Assessment Group (BILAG) score, reliable molecular biomarkers for monitoring d...
ORGANISM(S): Homo sapiens (Human) 
2026-06-22 | PXD075349 | Pride
Biomarker Shap values Explainable ai (xai) Cytokine Multi-omics Machine learning Proteomics Precision medicine 
TranscriptomicsSmall nucleolar RNA and microRNA expression data from multiple sclerosis patients in relapse and remission.
Multiple sclerosis is a common inflammatory and degenerative disease that causes neurological disability. It affects young adults and its prevalence is higher in women. The most common form is manifested as a series of acute episodes of neurological disability (relapses) followed by a recovery phase...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-74579 | biostudies-arrayexpress
ProteomicsIdentification of a Stable Stool Peptidomic Signature for Monitoring IBD Activity
Introduction Monitoring disease activity in inflammatory bowel disease (IBD) is essential for guiding therapy and preventing irreversible tissue damage. Colonoscopy, although the gold standard, is invasive and unsuitable for frequent monitoring, while fecal calprotectin lacks accuracy within its dia...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD074117 | Pride
Human Peptidomics Machine learning Inflammatory bowel disease Biomarker discovery Proteomics Stool Clinical mass spectrometry Nested cross validation Ibd activity 
TranscriptomicsExpression data from macrophages isolated from lupus NZB/W mouse kidneys prenephritic, nephritic or after complete remission.
Renal infiltration with mononuclear cells is associated with poor prognosis in SLE. A renal macrophage/dendritic cell signature is associated with onset of nephritis in NZB/W mice and immune modulating therapies can reverse this signature and the associated renal damage despite ongoing immune comple...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-27045 | biostudies-arrayexpress
TranscriptomicsIntegration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia
B-cell precursor acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer. Although the genetic origin of the disease remains unclear, epigenetic modifications including DNA methylation are suggested to contribute significantly to leukemogenesis. We assessed the DNA methylation s...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-38235 | biostudies-arrayexpress
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