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ProteomicsProteogenomics reveals two distinct biological pilocytic astrocytoma subgroups
Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and driven by aberrant MAPK signaling, typically mediated by BRAF alterations. While five-year overall survival rates exceed 95%, tumor recurrence constitutes a major clinical challenge in incompletely resected tumors despite chemot...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035773 | Pride
Lc-msms Pilocytic astrocytoma Brain tumour 
TranscriptomicsArray-CGH screening of pediatric low-grade astrocytomas (n=66)
DNA copy-number profiling of 66 astrocytomas of WHO °I or °II Comparison of tumor DNA (tumor) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comparative genomic hybridization (aCGH). Tumor DNA labeled in Cy...
ORGANISM(S): Homo sapiens 
2007-08-10 | E-GEOD-8737 | biostudies-arrayexpress
TranscriptomicsmRNA Expression Profiling of pooled medulloblastoma samples
mRNA expression analysis of 4 different pools of medulloblastoma samples with characteristic cytogenetic aberrations Keywords: Genetic modification Comparison of tumor RNA 1 (equally represented, pooled mRNA of tumors with cytogenetic aberration 1) versus tumor RNA (equally represented, pooled mRN...
ORGANISM(S): Homo sapiens 
2010-07-09 | E-GEOD-22823 | biostudies-arrayexpress
TranscriptomicsArray-CGH screening of pediatric T-lymphoblastic leukemias (n=73)
DNA copy-number profiling of 73 T-ALLs Keywords: Genetic modification Comparison of tumor DNA (tumor) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comparative genomic hybridization (aCGH). Tumor DNA label...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-8738 | biostudies-arrayexpress
UnknownCytogenetic prognostication within medulloblastoma subgroups.
Not available
S-EPMC3948094 | biostudies-literature
UnknownBRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
Not available
S-EPMC4356711 | biostudies-literature
UnknownGenome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53-Associated Cancer Susceptibility.
Not available
S-EPMC6366343 | biostudies-literature
TranscriptomicsRelative spatial heterogeneity revealed by transcriptional profiling of multi-region high-grade glioma samples
Affymetrix GeneChip® Human Genome U133 Plus 2.0 Array profiling of 20 primary, multi-region high-grade glioma samples. Total RNA was extracted from primary high-grade glioma samples and hybridized to GeneChip® Human Genome U133 Plus 2.0 Array according to the manufacturer's instructions.
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-62802 | biostudies-arrayexpress
UnknownTherapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
Not available
S-EPMC4962737 | biostudies-literature
TranscriptomicsMethylation profiling data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49377 | biostudies-arrayexpress
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