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TranscriptomicsTranscription profiling of human Ewing sarcoma primary tumors of patients to determine molecular predictors of outcome.
The improvement of Ewing's sarcoma (EWS) therapy is currently linked to find strategies to select patients with poor and good prognosis at diagnosis and to generate modified treatment regimens. In this study, we analyze the molecular factors governing EWS response to chemotherapy in order to ide...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12102 | biostudies-arrayexpress
Transcriptomicsmicroarray of healthy heart tissue of mouse (BALB/c nude female mice) after proton-beam treatment to cure breast cancer
Proton irradiation: 2, 6 and 9 Gy + untreated controls Times after irradiation: 3 and 10 days Associated pubblication: Sala, C.; Tarozzi, M.; Simonetti, G.; Pazzaglia, M.; Cammarata, F.P.; Russo, G.; Acquaviva, R.; Cirrone, G.A.P.; Petringa, G.; Catalano, R.; et al. Impact on the Transcriptome of ...
ORGANISM(S): Mus musculus 
2024-04-30 | E-MTAB-14006 | biostudies-arrayexpress
TranscriptomicsEpigenetic and transcriptomic signature of aging in human liver [expression]
Gene expression profiling of liver biopsies collected from 33 healthy liver donors ranging from 13 to 90 years old. The Affymetrix HG-U133 Plus 2.0 GeneChip platform was used to evaluate gene-expression. Total RNA (including miRNAs) was extracted using the mirVana miRNA Isolation Kit (Ambion); cDNA ...
ORGANISM(S): Homo sapiens 
2018-09-11 | E-GEOD-107037 | biostudies-arrayexpress
TranscriptomicsIdentification of a DNA methylation signature in blood from subjects affected by Down syndrome
Down syndrome is characterized by a wide spectrum of clinical signs, which include cognitive and endocrine disorders and haematological abnormalities. Although it is well established that the causative defect of Down syndrome is the trisomy of chromosome 21, the molecular bases of Down syndrome phen...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-52588 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human lymphoblastoid cell lines
Human lymphoblastoid cell lines (EBV-immortalised B cells, LcL) obtained from subjects of different age (young 28-40 years, centenarians >95 years) were analysed for gene expression at basal culture conditions and after 48 hours of serum starvation. Lymphoid B cells from centenarians were more resis...
ORGANISM(S): Homo sapiens 
2011-07-29 | E-GEOD-31040 | biostudies-arrayexpress
TranscriptomicsStudy of gene expression of peripheral blood T lymphocytes from age-series of monozygotic twin couples
In this study we analyse a gene expression dataset, obtained by microarray hybridization, consisting of T lymphocytes from 27 healthy monozygotic twin couples with ages ranging over whole adult lifespan (22 to 98 years). This peculiar experimental design, combined with a ridge regression approach, a...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-74937 | biostudies-arrayexpress
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