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MetabolomicsUntargeted Metabolomics Reveals a Mild Impact of Remote Ischemic Conditioning on the Plasma Metabolome and α-Hydroxybutyrate as a Possible Cardioprotective Factor and Biomarker of Tissue Ischemia
Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. heart attacks. As RIC can be induced using a simple blood pressure cuff e.g. prior to revascularization, it con...
2016-12-20 | MTBLS414 | MetaboLights
TranscriptomicsRemote ischemic preconditioning in on-pump coronary artery bypass graft surgery
In this placebo-controlled randomized controlled trial, we tested whether remote ischemic preconditioning (RIPC) elicited by four 5-minute cycles of 300 mmHg of cuff inflation/deflation of the lower limb would reduce myocardial necrosis in isoflurane-anesthetized patients undergoing on-pump coronary...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-29396 | biostudies-arrayexpress
ProteomicsAttenuated inflammatory profile following single and repeated handgrip exercise and remote ischemic preconditioning in patients with cerebral small vessel disease
Similar to remote ischemic preconditioning bouts of exercise may possess immediate protective effects against ischemia-reperfusion injury. However, underlying mechanisms are largely unknown. This study compared the impact of single and repeated handgrip exercise versus remote ischemic preconditionin...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037267 | Pride
Exercise Inflammation Remote ischemic preconditioning Cerebral small vessel disease Proteomics. 
TranscriptomicsThe analysis of differential gene expression after remote ischemic preconditioning of renal ischemia reperfusion injury
To investigate the mechanism by which ischemic preconditioning (IPC) produces tissue tolerance to renal ischemia reperfusion injury in a pig model 15 female Yorkshire pigs were divided into three groups: 1: no IPC and 90 minutes warm ischemia; 2: remote IPC with an early window followed by 90 min wa...
ORGANISM(S): Sus scrofa 
2016-09-02 | E-GEOD-72646 | biostudies-arrayexpress
TranscriptomicsGlobal Gene Expression in Deceased Donor Liver Transplantation with Ischemic Preconditioning
The clear benefits of ischemic preconditioning (IPC) in reducing ischemia reperfusion injury (IRI) remain indistinct in human liver transplantation. To further understand the mechanistic aspects of IPC in human deceased donor liver transplantation (DDLT), we performed microarray analyses to determin...
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15480 | biostudies-arrayexpress
GenomicsGenome-wide profiling of cardiac H3K9me2 levels in response to ischemic preconditioning
H3K9me2 ChIP-Seq of cardiac biopsies from the area at at risk and remote myocardium of mice subjected to ischemic preconditioning. Mice were subjected to ischemic preconditioning (IPC) through reversible ligation of the left coronary artery or a sham procedure. The procedure consisted of 5 minutes o...
ORGANISM(S): Mus musculus 
2016-07-04 | E-GEOD-83979 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of cardiac biopsies from mice subjected to ischemic preconditioning
Microarray profiling of cardiac biopsies from the area at at risk and remote myocardium of mice subjected to ischemic preconditioning. Mice were subjected to ischemic preconditioning (IPC) through reversible ligation of the left coronary artery or a sham procedure. The procedure consisted of 4 minut...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-83659 | biostudies-arrayexpress
ProteomicsThe human plasma proteome before and after remote ischemic preconditioning
Six healthy male adults underwent RIPC, consisting of 3x5 min cycles of upper arm ischemia (inflating a blood pressure cuff to >200 mmHg) alternating with 3x5 min reperfusion (bp cuff deflated). Blood samples were collected at baseline and at 1 and 4 min into each reperfusion period. Plasma was isol...
ORGANISM(S): Homo sapiens (Human) 
2014-09-16 | PXD000605 | Pride
Remote ischemic preconditioning Plasma Human 
ClinicalEffect of remote ischemic preconditioning on postoperative gastrointestinal function in patients undergoing laparoscopic colorectal cancer resection
Interventions: RIPC group(Group R):Remote ischemia preconditioning;Control group (Group C):Sham remote ischemic preconditioning Primary outcome(s): Postoperative I-FEED score Study Design: Parallel
38105 | ecrin-mdr-crc
ClinicalProtective effect of remote ischemic preconditioning combined with sevoflurane posttreatment on myocardial injury during laparoscopic radical resection of colorectal cancer
Interventions: total intravenous anesthesia:Propofol anesthesia;Sevoflurane posttreatment:Sevoflurane anesthesia;Propofol combined with sevoflurane anesthesia:Propofol combined with sevoflurane anesthesia;RIPC and propofol anesthesia:Remote ischemic preconditioning and propofol anesthesia;RIPC and s...
2703482 | ecrin-mdr-crc
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