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MetabolomicsMetabolomic Profiling of Renal Cyst Fluid in Advanced ADPKD: Insights from Dialysis and Transplantation Cohorts

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). While urinary metabolomics in ADPKD has been extensively studied, the composition of renal cyst fluid, par...

2025-07-07 | MTBLS12372 | MetaboLights
TranscriptomicsGenome-wide gene expression profiles of clear cell renal cell carcinoma; Identification of molecular targets for treatment of renal cell carcinoma
In order to clarify the molecular mechanism involved in renal carcinogenesis, and identify molecular targets for diagnosis and treatment, we analyzed genome-wide gene expression profiles of 15 surgical specimens of clear cell renal cell carcinoma (RCC), compared to normal renal cortex, using a combi...
ORGANISM(S): Homo sapiens 
2012-07-15 | E-GEOD-39364 | biostudies-arrayexpress
TranscriptomicsIntragraft transcriptional profiling of renal transplant patients with tubular dysfunction after distinct immunosuppressive regimens
Intragraft transcriptional profiles were investigated in patients with tubular dysfunction to disclose subclinical mechanisms underlying graft deterioration. Moreover, we analyzed whether individualization of immunosuppression could modify this profile while improving renal function after 12 months ...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-48250 | biostudies-arrayexpress
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+diet analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4994 | MetaboLights
MetabolomicsSterol-O acyltransferase inhibition ameliorates high-fat diet-induced renal fibrosis and tertiary lymphoid tissue maturation after ischemic reperfusion injury (Mice+injury analysis)

Metabolic syndrome is a growing global health problem and is strongly associated with the development of chronic kidney disease (CKD). Recently, the prevalence of CKD has been increasing worldwide, particularly among the older adults. We previously demonstrated that aged kidneys are prone to deve...

2022-12-05 | MTBLS4988 | MetaboLights
ProteomicsMetabolomic and Proteomic Analysis of Renal Function After Liver Transplantation
Background: Renal dysfunction is a common and serious complication in patients with end-stage liver diseases. While some patients recover renal function after liver transplantation (LT), others do not. Additionally, patients with normal kidney function (Normal-KF) before LT may develop post-transpla...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD062924 | Pride
Proteomics Metabolomics Renal dysfunction Liver transplantation 
ProteomicsProteomic analysis of clear cell renal cell carcinoma tissue versus matched normal kidney tissue
We analyzed 84 tumor/normal pairs (177 total) using standard shotgun proteomic techniques in order to characterize the molecular landscape of clear cell renal cell carcinoma (ccRCC) and interrogated changes in protein abundance and biological pathways with ccRCC grade. These tissues were distributed...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079972 | MassIVE
TranscriptomicsRenal allograft dysfunction
The study comprises various components: We aim to screen out different gene expression profile in acute rejection on the kidney. We aim to screen out different gene expression profile in acute tubular necrosis on the kidney. We aim to screen out different gene expression profile in borderline change...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19130 | biostudies-arrayexpress
TranscriptomicsBorderline Changes in Renal Allografts: Molecular Diagnostics Identifies Risks for Graft Dysfunction
The significance of borderline changes (BL) in kidney allograft biopsies is widely debated. We examined differences in gene expression patterns between early clinical biopsy tissue and 3-month protocol biopsy tissue, all of which had histological BL changes and identified specific molecular BL patte...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-52694 | biostudies-arrayexpress
TranscriptomicsExpression data from human renal allograft biopsies to investigate renal transplant rejection and failure
Kidney transplants that develop dysfunction or proteinuria after one year post transplant are at considerable risk for progression to renal failure. Identifying the molecules associated with graft failure could potentially lead to interventions that would slow the progression of organ failure. We an...
ORGANISM(S): Homo sapiens 
2010-05-24 | E-GEOD-21374 | biostudies-arrayexpress
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