Borderline Changes in Renal Allografts: Molecular Diagnostics Identifies Risks for Graft Dysfunction

ABSTRACT: The significance of borderline changes (BL) in kidney allograft biopsies is widely debated. We examined differences in gene expression patterns between early clinical biopsy tissue and 3-month protocol biopsy tissue, all of which had histological BL changes and identified specific molecular BL patterns associated with poor graft outcome. The expression profiles were analyzed in training set of patients and next data were validated in validation cohort using RT-qPCR. Using the Illumina microarray technology, we observed greater expression of immunity- and inflammation-related genes in tissues from early clinical biopsies compared to 3-month protocol biopsies with BL findings. In tissues with early clinically manifested BL changes, graft deterioration within 24 months due to chronic rejectio

ORGANISM(S): Homo sapiens

SUBMITTER: Petra Hruba 

PROVIDER: E-GEOD-52694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress