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MetabolomicsMetabolomic Profiling of Renal Cyst Fluid in Advanced ADPKD: Insights from Dialysis and Transplantation Cohorts

Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary disorder characterized by progressive renal cyst formation, often leading to end-stage kidney disease (ESKD). While urinary metabolomics in ADPKD has been extensively studied, the composition of renal cyst fluid, par...

2025-07-07 | MTBLS12372 | MetaboLights
TranscriptomicsEarly introduction of oral paricalcitol in renal transplant recipients
In stable renal transplant recipients with hyperparathyroidism, the vitamin D agonist paricalcitol reduces the level of proteinuria. Animal studies have indicated possible anti-fibrotic and anti-inflammatory effects of paricalcitol. We hypothesised that early introduction of paricalcitol in de novo ...
ORGANISM(S): Homo sapiens 
2017-09-01 | E-GEOD-83486 | biostudies-arrayexpress
TranscriptomicsIntragraft transcriptional profiling of renal transplant patients with tubular dysfunction after distinct immunosuppressive regimens
Intragraft transcriptional profiles were investigated in patients with tubular dysfunction to disclose subclinical mechanisms underlying graft deterioration. Moreover, we analyzed whether individualization of immunosuppression could modify this profile while improving renal function after 12 months ...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-48250 | biostudies-arrayexpress
TranscriptomicsIdentification of a B cell signature associated with renal transplant Tolerance in humans
In this study, investigators recruited the largest reported cohort of tolerant kidney transplant recipients who maintained their graft after ceasing to take their immunosuppression drug, and compared this cohort to subjects with stable allograft function while on immunosuppression and healthy non t...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-22229 | biostudies-arrayexpress
TranscriptomicsExpression data from human renal allograft biopsies to investigate renal transplant rejection and failure
Kidney transplants that develop dysfunction or proteinuria after one year post transplant are at considerable risk for progression to renal failure. Identifying the molecules associated with graft failure could potentially lead to interventions that would slow the progression of organ failure. We an...
ORGANISM(S): Homo sapiens 
2010-05-24 | E-GEOD-21374 | biostudies-arrayexpress
TranscriptomicsGene Expression Test for Operational Renal Allograft Tolerance
Genomic Analysis of more than 400 patients from multi-center transplant programs and clinical trials provides a non-invasive QPCR based gene expression test for operational renal allograft tolerance 3 group comparison of blood from TOL, CAN and Non-transplant healthy controls (HD) allografts. Biolog...
ORGANISM(S): Homo sapiens 
2015-01-08 | E-GEOD-45218 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis in human kidney to investigate whether fibrosis with inflammation at one year post transplant predicts transplant functional decline
We previously observed reduced graft survival for kidney transplants having interstitial fibrosis with subclinical inflammation, but not fibrosis alone, on 1-year protocol biopsy. The current study aimed to determine whether fibrosis with inflammation at 1 year is associated with renal functional de...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-22459 | biostudies-arrayexpress
Proteomics,MultiomicsMining the Human Urine Proteome for Monitoring Renal Transplant Injury
a) 8-plex iTRAQ-based quantitative proteomics analysis of the urine proteome comparing 4 different clinical conditions; b) Label-free LC-MS analyses of individual urine samples from different clinical conditions
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-08-18 | MSV000079262 | MassIVE
TranscriptomicsThe clinical and genomic significance of donor-specific antibody (DSA) positive/C4d negative and DSA negative/C4d negative transplant glomerulopathy
We investigated the clinical, histopathologic and genomic features of donor-specific antibody (DSA) +/C4d- and DSA-/C4d- transplant glomerulopathy (TGP) using microarrays. Comparison of the gene expression profiles of DSA-/C4d- TGP biopsies with ptc+g score > 1 to normal and IFTA (Interstitial Fibr...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44131 | biostudies-arrayexpress
GenomicsRenal transplant microbiome
Renal transplant microbiome Raw sequence reads
PRJNA540316 | ENA
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