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ProteomicsEquine muscle-derived mesenchymal stem cells protect cartilage explants in osteoarthritis model: secretome characterization
Background: Osteoarthritis is a highly prevalent joint degenerative disease for which therapeutic treatments are limited or invasive. Cell therapy based on mesenchymal stem/stromal cells (MSCs) is therefore seen as a promising approach for this disease, in both human and horses. Objective: As the r...
ORGANISM(S): Equus caballus (Horse) 
2022-11-08 | PXD031924 | Pride
Stem cells  equine Secretome 
ProteomicsEndogenous TOM20 proximity labelling: a Swiss-knife for the study of mitochondrial proteins in human cells
The majority of mitochondrial proteins are encoded by the nuclear genome and must be imported into the mitochondria. There are two main paths for mitochondrial protein import: post-translational and co-translational import. Co-translational import couples the translation and the translocation of the...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD038821 | Pride
Mitochondria  co-translational import  bioid  protein identification  mass spectrometry 
ProteomicsThe global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation
Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation both at the global and transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic differentiation of induced pluripotent stem cells (iPSCs) by pol...
ORGANISM(S): Homo sapiens (Human) 
2022-12-26 | PXD038204 | Pride
Translational regulation Top mrna Hepatocyte differentiation Stem cells 
ProteomicsOptimization of label-free nano LC-MS/MS analysis of the placental proteome
We optimized a protocol to analyze the placental proteome by means of label-free nano-LC-MS/MS mass spectrometry with regard to sample treatment, protein extraction, and protein digestion, in order to obtain a high protein concentration for identification of a specific protein signature according to...
ORGANISM(S): Homo sapiens (Human) 
2020-10-13 | PXD020438 | Pride
Placenta Lc-msms 
ProteomicsThe lipid transport Mla Pqi Chimeric system is essential for Brucella abortus survival in macrophages
Envelope integrity is essential for diderm bacteria. The envelope is composed of an inner membrane (IM) and an outer membrane (OM), which are separated by a periplasmic space. Several pathways have been recently identified that facilitate the transport of phospholipids between the two membranes in E...
ORGANISM(S): Brucella abortus 
2025-06-19 | PXD057244 | Pride
Lipid transport  outer membrane biogenesis  gram negative cell envelope  pqi  mla  envelope spanning  brucella 
ProteomicsAn organ-specific angiogenic control mechanism for endothelial tailoring.
Each organ of the human body requires locally-adapted blood vessels1–3. The gain of such organotypic vessel specializations is often deemed molecularly unrelated to the process of organ vascularization. Opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operate...
ORGANISM(S): Homo sapiens (Human) 
2024-02-08 | PXD042613 | Pride
Angiogenesis  tip cell angiodiversity  wnt/β-catenin signaling  blood-brain barrier  bbb  mmp25  col4a5  col4a6  pial fibroblast  gpr124  reck  wnt7a 
ProteomicsEvidence that Dmrta2 acts through repression of Pax6 in cortical patterning and identification of a mutation crucial for DNA recognition associated with microcephaly in human
Dmrta2 (also designated Dmrt5) is a transcriptional regulator expressed in cortical progenitors in a caudomedial high/rostrolateral low gradient with important roles at different steps of cortical development. Dmrta2 has been suggested to act in cortex development mainly by differential suppression ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-30 | PXD062221 | Pride
Cerebral cortex Neural progenitor Neurogenesis Transcription factor. 
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