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TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
ProteomicsIdentification of tomato proteins that interact with Replication initiator protein (Rep) of the geminivirus TYLCV
In this study, an GFP-based affinity purification followed by mass spectrometry (AP-MS) approach is used in order to identify new tomato proteins that interact with the Replication initiator protein (Rep, AL1, C1) from Tomato yellow leaf curl virus (TYLCV).
ORGANISM(S): Tomato yellow leaf curl virus Solanum lycopersicum 
2020-07-10 | PXD018011 | Pride
Proteomics Rep Viral replication Geminivirus Interactome Tylcv Pcna 
GenomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Dnase-Seq]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-59782 | biostudies-arrayexpress
GenomicsComprehensive mutagenesis of AAV2 rep
Comprehensive mutagenesis of AAV2 rep
PRJNA939270 | ENA
OtherComprehensive mutagenesis of AAV2 rep
Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but production of sufficient rAAV quantities remains difficult. The AAV Rep proteins, which are essential for genome replication and packaging, rep...
ORGANISM(S): Adeno-associated virus 
2023-02-28 | GSE226265 | GEO
ProteomicsFor origin melting Rep nucleoprotein complex accommodates both dsDNA and ssDNA of DUE
The replication initiation proteins interact dsDNA located at replication origin and ssDNA of DNA unwinding element (DUE), formed as a result of the destabilization of the double-stranded helix of AT-rich origin region. It is a critical step in the DNA replication initiation; however, the structure ...
ORGANISM(S): Escherichia coli 
2024-01-26 | PXD032398 | Pride
Dna replication Rep proteins Protein-dna interaction Replication initiators Origin opening 
UnknownInducible HEK293 AAV packaging cell lines expressing Rep proteins.
Not available
S-EPMC10407821 | biostudies-literature
UnknownFunctional analysis of a novel motif conserved across geminivirus Rep proteins.
Not available
S-EPMC3020519 | biostudies-literature
UnknownMastrevirus Rep and RepA Proteins Suppress de novo Transcriptional Gene Silencing.
Not available
S-EPMC8584122 | biostudies-literature
TranscriptomicsOpen chromatin mapping identifies transcriptional networks regulating human epididymis epithelial function [Rnase-Seq]
The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-59781 | biostudies-arrayexpress
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