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MetabolomicsPorcine epidemic diarrhea virus manipulates IMPDH-dependent nucleotide biosynthesis to facilitate replication

Porcine epidemic diarrhea virus (PEDV) causes acute intestinal disease in pigs and remains a major threat to the global swine industry due to its high morbidity and mortality in neonatal piglets. To investigate host metabolic alterations upon PEDV infection, we performed untargeted metabolomic pr...

2025-10-17 | MTBLS13153 | MetaboLights
TranscriptomicsLoss of DNA replication control is a potent initiator of gene amplification
Eukaryotic cells use numerous mechanisms to ensure that no segment of their DNA is re-replicated within a single cell cycle. Despite longstanding speculation that such tight regulation is needed to protect cells from genomic alterations, this notion has never been experimentally tested. Here we show...
ORGANISM(S): Saccharomyces cerevisiae 
2011-05-17 | E-GEOD-22018 | biostudies-arrayexpress
ProteomicsThe Escherichia coli replication initiator DnaA is titrated on the chromosome
DNA replication initiation is orchestrated in bacteria by the replication initiator DnaA. Two models for regulation of DnaA activity in Escherichia coli have been proposed: the switch between an active and inactive form and the titration of DnaA on the chromosome. Although proposed decades ago, expe...
ORGANISM(S): Escherichia coli 
2025-07-28 | PXD064841 | Pride
Titration model Single-particle tracking photoactivatable localisation microscopy Switch model Dnaa protein Oric Dnaa boxes chromosome binding Data Replication initiator 
ProteomicsIdentification of tomato proteins that interact with Replication initiator protein (Rep) of the geminivirus TYLCV
In this study, an GFP-based affinity purification followed by mass spectrometry (AP-MS) approach is used in order to identify new tomato proteins that interact with the Replication initiator protein (Rep, AL1, C1) from Tomato yellow leaf curl virus (TYLCV).
ORGANISM(S): Tomato yellow leaf curl virus Solanum lycopersicum 
2020-07-10 | PXD018011 | Pride
Proteomics Rep Viral replication Geminivirus Interactome Tylcv Pcna 
TranscriptomicsGenome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis
This SuperSeries is composed of the following subset Series: GSE17980: Genome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (Expression) GSE17983: Genome-Wide Dynamics of Replication Timing Revealed by In Vitro Models of Mouse Embryogenesis (WG_CGH; Replicati...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-18019 | biostudies-arrayexpress
TranscriptomicsGenome-wide ParB2-DNA and RctB-DNA interaction analyses in Vibrio cholerae
Replication and segregation are the two main processes that maintain chromosomes in growing cells. In bacteria, replication and transcription have been proposed to provide motive force in chromosome segregation. Recently, ParB2, a segregation protein, encoded by V. cholerae chromosome II (chrII) wa...
ORGANISM(S): Vibrio cholerae O1 biovar El Tor str. N16961 
2015-09-14 | E-GEOD-72978 | biostudies-arrayexpress
TranscriptomicsAvoiding chromosome pathology when replication forks collide
Chromosome duplication normally initiates via the assembly of replication fork complexes at defined origins. DNA synthesis by any one fork is thought to cease when it meets another travelling in the opposite direction, at which stage the replication machinery may simply dissociate before the nascent...
ORGANISM(S): Escherichia coli 
2013-07-22 | E-GEOD-41975 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding of replication initiation proteins in Bacillus subtilis
Initiation of DNA replication requires binding of the initiator protein, DnaA, to specific binding sites in the chromosomal origin of replication, oriC. In low G+C Gram-positive bacteria, the primosomal proteins DnaD and DnaB, in conjunction with loader ATPase DnaI, load the replicative helicase at ...
ORGANISM(S): Bacillus subtilis 
2010-12-07 | E-GEOD-23686 | biostudies-arrayexpress
UnknownThe structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6.
Not available
S-EPMC8222357 | biostudies-literature
TranscriptomicsA unique epigenetic signature is associated with active DNA replication loci in human embryonic stem cells
The cellular epigenetic landscape changes as pluripotent stem cells differentiate to somatic cells or when differentiated cells transform to a cancerous state. These epigenetic changes are commonly correlated with differences in gene expression. Whether active DNA replication is also associated with...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-43152 | biostudies-arrayexpress
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