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MetabolomicsInfection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication
Peroxisomes are primarily metabolic organelles with important functions in lipid metabolism, such as fatty acid oxidation and ether phospholipid synthesis (e.g. plasmalogens). Certain viruses, such as human cytomegalovirus (HCMV), hijack organelle functions to facilitate their replication and spread...
2018-10-22 | MTBLS652 | MetaboLights
MetabolomicsA synthetic cell with integrated DNA self-replication and lipid biosynthesis

The emergence, organization, and persistence of cellular life are the result of the functional integration of metabolic and genetic networks. Here, we engineer phospholipid vesicles that can operate three essential functions, namely transcription-translation of a partial genome, self-replication ...

2026-02-02 | MTBLS13437 | MetaboLights
GenomicsC19orf66 is an interferon-induced inhibitor of HCV replication restricting formation of the viral replication organelle
C19orf66 is an interferon-induced inhibitor of HCV replication restricting formation of the viral replication organelle
PRJNA609133 | ENA
TranscriptomicsC19orf66 is an interferon-induced inhibitor of HCV replication restricting formation of the viral replication organelle
Hepatitis C virus (HCV) infection constitutes a global health problem with 71 million people currently chronically infected. Recent studies have reported that C19orf66 is expressed as an interferon (IFN)-stimulated gene; however, the intrinsic regulation of this gene within the liver as well as its ...
ORGANISM(S): Homo sapiens 
2020-02-28 | GSE146075 | GEO
UnknownThe role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.
Not available
S-EPMC7612910 | biostudies-literature
GenomicsDNA methyltransferases are required to induce heterochromatic re-replication in Arabidopsis.
The relationship between epigenetic marks on chromatin and the regulation of DNA replication is poorly understood. Mutation of the H3K27 methyltransferase genes, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5 (ATXR5) and ATXR6, result in re-replication (repeated origin firing within the same cell cycle). He...
ORGANISM(S): Arabidopsis thaliana 
2012-08-07 | E-GEOD-38286 | biostudies-arrayexpress
UnknownDeterminants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis.
Not available
S-EPMC8513467 | biostudies-literature
TranscriptomicsRif1 regulates initiation timing of late replication origins throughout the S. cerevisiae genome [array]
Chromosomal DNA replication involves the coordinated activity of hundreds to thousands of replication origins. Individual replication origins are subject to epigenetic regulation of their activity during S-phase, resulting in differential efficiencies and timings of replication initiation during S-...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-01 | E-GEOD-55130 | biostudies-arrayexpress
UnknownViral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication.
Not available
S-EPMC7077330 | biostudies-literature
UnknownArchitecture of the chikungunya virus replication organelle.
Not available
S-EPMC9633065 | biostudies-literature
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