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MetabolomicsConserved cellular signals and mechanisms accompany the reproductive shutdown of honey bee (Apis mellifera) queens for dispersal
Temporal reproductive plasticity is a central life-history trait for most iteroparous animals, yet its underlying molecular mechanisms remain poorly understood. We utilize the reversible reproductive arrest experienced by honey bee queens during colony swarming to investigate how these reproductive ...
2026-04-09 | MTBLS14234 | MetaboLights
MetabolomicsUridine restores oocyte quality and mitigates female reproductive aging by inhibition of ferroptosis in mice

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
MetabolomicsImpact of reproductive activity on physiological metabolism and molecular regulation in the Genus scallopus(Mizuhopecten yessoensis)

Genus scallopus(Mizuhopecten yessoensis), a commercially important shellfish species in China, suffers a persistently high post-spawning mortality rate, severely constraining industry development. Thus, this study investigated the physiological and molecular impact of reproductive activity on M. ...

2025-06-28 | MTBLS12652 | MetaboLights
MetabolomicsL-Citrulline and L-arginine regulate the reproductive performance of young and adult cows through distinct metabolic pathways and the shared pyrimidine metabolic pathway respectively

(Background)To investigate the impact of L-arginine (L-Arg) and L-citrulline (L-Cit) on cow reproductive performance.(Methods) 90 healthy, age-matched Simmental cows were randomly assigned to three groups: control, L-Arg, and L-Cit, with 30 cows per group. Estrus synchronization was performed, an...

2025-07-05 | MTBLS12682 | MetaboLights
MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
TranscriptomicsEffects of drought on gene expression in Maize reproductive and leaf meristem tissue revealed by RNA-seq
Purpose: To study the effects of drought at the transcriptomic level on two different actively dividing maize tissue: the ovaries, and the leaf meristem Methods: The Illumina reads were mapped to the maize B73 reference genome using Tophat followed by transcriptome reconstruction using Cufflinks. T...
ORGANISM(S): Zea mays 
2012-08-14 | E-GEOD-40070 | biostudies-arrayexpress
TranscriptomicsTimecourse of gene expression after oprhaning of virgin Solenopsis invicta fire ant queens
In species with social hierarchies, the death of dominant individuals typically upheaves the social hierarchy and provides an opportunity for subordinate individuals to become reproductives. Such a phenomenon occurs in the monogyne form of the fire ant, Solenopsis invicta, where colonies typically c...
ORGANISM(S): Solenopsis invicta 
2010-01-31 | E-GEOD-19721 | biostudies-arrayexpress
TranscriptomicsRNA-Seq expression data from the reproductive tracts of WT, Hoxa91011, and Hoxd91011 mutant mice
Hox genes are key regulators of development. In mammals, the study of these genes is greatly confounded by their large number, overlapping functions, and their interspersed shared enhancers. In this report, we describe a novel recombineering strategy that was used to introduce simultaneous frameshif...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-42339 | biostudies-arrayexpress
TranscriptomicsExpression data from MTDH knockdown in the Hec50co endometrial cancer cell line
Understanding the molecular underpinnings of chemoresistance is vital to design therapies to restore chemosensitivity. In particular, metadherin (MTDH) has been demonstrated to have a critical role in chemoresistance. Over-expression of MTDH has recently been implicated in poor clinical outcome in b...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-26134 | biostudies-arrayexpress
TranscriptomicsOogenesis in Solea senegalensis: Previtellogenic versus vitellogenic ovaries
Transcriptionnal profile changes in ovary during the reproductive cycle of Solea senegalensis: from previtellogenic stage to vitellogenic stage obtained at different times during the annual reproductive cycle. An oligo microarray based on ESTs sequenced from S. senegalensis previously designed (Cerd...
ORGANISM(S): Solea senegalensis 
2010-06-21 | E-GEOD-17336 | biostudies-arrayexpress
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