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MetabolomicsFecal metabolites in sows of different reproductive potential

Placental dysplasia critically impairs fetal growth and development by disrupting nutrient supply. Thiamine, predominantly in its bioactive form thiamine pyrophosphate, serves as an essential coenzyme in mitochondrial energy metabolism, yet its regulatory role in placental development remains elu...

2025-07-29 | MTBLS12795 | MetaboLights
MetabolomicsImpact of reproductive activity on physiological metabolism and molecular regulation in the Genus scallopus(Mizuhopecten yessoensis)

Genus scallopus(Mizuhopecten yessoensis), a commercially important shellfish species in China, suffers a persistently high post-spawning mortality rate, severely constraining industry development. Thus, this study investigated the physiological and molecular impact of reproductive activity on M. ...

2025-06-28 | MTBLS12652 | MetaboLights
MetabolomicsL-Citrulline and L-arginine regulate the reproductive performance of young and adult cows through distinct metabolic pathways and the shared pyrimidine metabolic pathway respectively

(Background)To investigate the impact of L-arginine (L-Arg) and L-citrulline (L-Cit) on cow reproductive performance.(Methods) 90 healthy, age-matched Simmental cows were randomly assigned to three groups: control, L-Arg, and L-Cit, with 30 cows per group. Estrus synchronization was performed, an...

2025-07-05 | MTBLS12682 | MetaboLights
MetabolomicsLipidomics study for investigating the role of the Unfolded Protein Response In Arabidopsis seed filling

The Unfolded Protein Response (UPR) is a retrograde, ER-to-nucleus, signalling pathway which is conserved across kingdoms. In plants, it contributes to development, reproduction, immunity and tolerance to abiotic stress. This lipidomic dataset was produced from Arabidopsis thaliana mature seeds. ...

2024-12-02 | MTBLS10597 | MetaboLights
TranscriptomicsTranscription profiling of zebrafish ovary treated with the reproductive toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
2,3,7,8-TCDD (TCDD) is a reproductive toxicant and endocrine disruptor in nearly all vertebrates, yet the mechanisms by which TCDD induces these reproductive alterations have not been fully characterized. Fish are among the most sensitive vertebrates to the toxic effects of TCDD, and even subtle ph...
ORGANISM(S): Danio rerio 
2009-04-30 | E-GEOD-4859 | biostudies-arrayexpress
ProteomicsCompartmentalization and modulation of reproductive protein networks in response to experimental sexual selection
Here we directly test the hypothesis that PCSS results in rapid evolution of the entire male accessory gland proteome and protein networks by taking a system-level approach, combining divergent experimental evolution of PCSS in Drosophila pseudoobscura (Dpse), high resolution mass spectrometry (MS) ...
ORGANISM(S): Drosophila pseudoobscura (Fruit fly) 
2019-02-18 | PXD012545 | Pride
Reproductive protein networks 
ProteomicsAstral-DIA Proteomics Deciphers the Molecular Landscape of Human Spermatozoa: A Comprehensive Quantitative Proteomic Characterization of Sperm Function and Fertility Potential
Male infertility is fundamentally rooted in developmental defects of germ cells and associated molecular dysregulation, yet the underlying mechanisms remain poorly understood. Data-independent acquisition (DIA) has emerged as a powerful tool in discovery proteomics, enabling the identification of di...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD061698 | Pride
Astral-dia  proteomics deciphers  molecular landscape 
MetabolomicsPaternal microbiome perturbations impact offspring fitness

The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, t...

2024-02-12 | MTBLS1629 | MetaboLights
GenomicsCharacterization of SOC1’s central role in flowering by the identification of its upstream and downstream regulators
The transition from vegetative to reproductive development is one of the most important phase changes in the plant life cycle. This step is controlled by various environmental signals that are integrated at the molecular level by so-called floral integrators. One such floral integrator in Arabidopsi...
ORGANISM(S): Arabidopsis thaliana 
2013-04-09 | E-GEOD-45846 | biostudies-arrayexpress
OtherSystematic analysis of the phosphoproteome and kinase-substrate networks in the mouse testis.
Data from ProteomeXchange, PXD ID: PXD000767. Experiment: IMAC-1, file: mmtestis-5mg-SCX_ID9_6mm-IMACenriched-ql-0-2.mzXML. Published as part of Mol Cell Proteomics. 2014 Oct 7 . From the Abstract: {{i}} ... Here we present an integrative study of phosphorylation events in the testis. Large-scale p...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320004513 | GPMDB
Resource Reanalysis 
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