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ProteomicsFelipe Sheep EV DIA LC/MS/MS using the Orbitrap Astral
DIA analysis of sheep EVs using Evosep one and Orbitrap Astral
ORGANISM(S): Ovis aries 
2026-09-14 | PXD077206 | Pride
Ev Dia Astral Sheep 
ProteomicsAstral-DIA Proteomics Deciphers the Molecular Landscape of Human Spermatozoa: A Comprehensive Quantitative Proteomic Characterization of Sperm Function and Fertility Potential
Male infertility is fundamentally rooted in developmental defects of germ cells and associated molecular dysregulation, yet the underlying mechanisms remain poorly understood. Data-independent acquisition (DIA) has emerged as a powerful tool in discovery proteomics, enabling the identification of di...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD061698 | Pride
Astral-dia  proteomics deciphers  molecular landscape 
ProteomicsDSS induced colitis mice Astral-DIA
This study aims to investigate the protein expression profiles in a murine model of dextran sulfate sodium (DSS)-induced colitis using advanced Astral-DIA quantitative proteomics technology. A total of 12 colon tissue samples were analyzed, including 6 from healthy control mice and 6 from DSS-treate...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-18 | PXD063633 | Pride
Dss Mice Colon 
ProteomicsAstral-DIA Proteomics Deciphers the Molecular Landscape of Human Spermatozoa: A Comprehensive Quantitative Proteomic Characterization of Sperm Function and Fertility Potential
Male infertility is fundamentally rooted in developmental defects of germ cells and associated molecular dysregulation, yet the underlying mechanisms remain poorly understood. Data-independent acquisition (DIA) has emerged as a powerful tool in discovery proteomics, enabling the identification of di...
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD061638 | Pride
Astral-dia  proteomics  human spermatozoa  sperm function 
ProteomicsSystematic Proteome-Wide Target Interrogation of PROTAC activity by High-Throughput DIA-MS on the Orbitrap Astral Platform
An efficient degradation-based proteomics workflow was established using data-independent acquisition-mass spectrometry (DIA-MS) and the Orbitrap Astral platform to investigate the mode of actions (MOA) and on target specificity of bromodomain and extra-terminal (BET) protein-targeting PROTACs, MZ1 ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-05 | PXD069438 | Pride
Proteomics Dia-ms Bromodomain containing proteins Orbitrap astral Proteolysis targeting chimeras 
ProteomicsNarrow-window DIA: Ultra-fast quantitative analysis of comprehensive proteomes with high sequencing depth. Evaluation of window width and injection time.
Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes in a fast and reproducible manner. Here, we present an ultra-fast scanning data-independent acquisition (DIA) strategy consisting on 2-Th precursor isolation windows, dissolving the differences between data-dependen...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD046285 | Pride
Dia Astral Proteomics 
ProteomicsAbundance analysis of chromatin-residing proteins during lineage conversion using protein aggregation capture (PAC)
We performed abundance analysis of chromatin-residing proteins in BLaER1 cells during the early stages of B-cell-to-macrophage transdifferentiation. We employed protein aggregation capture (PAC) to analyze chromatin-residing protein abundances at 0, 6 and 24 h after induction of transdifferentiation...
ORGANISM(S): Homo sapiens (Human) 
2026-05-27 | PXD076495 | Pride
Mass spectrometry Transdifferentiation Human Chromatin Blaer1 
ProteomicsNarrow-window DIA: Ultra-fast quantitative analysis of comprehensive proteomes with high sequencing depth. Dilution Series and Single Shot Gradient comparison.
Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes in a fast and reproducible manner. Here, we present an ultra-fast scanning data-independent acquisition (DIA) strategy consisting on 2-Th precursor isolation windows, dissolving the differences between data-dependen...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD046283 | Pride
Dia Astral Proteomics 
ProteomicsUltra-fast label-free quantification andcomprehensive proteome coveragewith narrow-window data-independentacquisition. DDA vs DIA comparison
Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes in a fast and reproducible manner. Here, we present an ultra-fast scanning data-independent acquisition (DIA) strategy consisting on 2-Th precursor isolation windows, dissolving the differences between data-dependen...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD046453 | Pride
Dia Astral Proteomics 
ProteomicsUltra-fast label-free quantification andcomprehensive proteome coveragewith narrow-window data-independentacquisition. Fractionation
Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes in a fast and reproducible manner. Here, we present an ultra-fast scanning data-independent acquisition (DIA) strategy consisting on 2-Th precursor isolation windows, dissolving the differences between data-dependen...
ORGANISM(S): Homo sapiens (Human) 
2024-02-01 | PXD046372 | Pride
Dia Astral Proteomics 
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