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TranscriptomicsTranscription profiling of yeast rho0 cells (complete deletion of the mitochondrial genome), in cells with either a single defective enzyme or several, vs cells after prolonged treatment with the bc1 inhibitors myxothiazol or antimycin to analyse respiratory defects
The mitochondrial respiratory chain is composed of lipoprotein complexes imbedded in the inner mitochondrial membrane. This chain of enzymes transfers electrons from NADH and FADH2, provided from divers metabolic pathways, to oxygen. It couples the transfer of electrons to the translocation of proto...
ORGANISM(S): Saccharomyces cerevisiae 
2009-02-20 | E-MEXP-585 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by MV130 (Bactek®) in human monocytes-derived dendritic cells.
MV130 is a commercially polyvalent bacterial preparation, which has shown to reduce the the rate of respiratory infections in patients suffering from recurrent respiratory tract infections. However, the immunological mechanisms associated to this clinical benefit remain unknown. We wanted to identif...
ORGANISM(S): Homo sapiens 
2017-12-14 | E-MTAB-5259 | biostudies-arrayexpress
TranscriptomicsComparison of bone marrow-derived macrophages from BALB/c and C57BL/6 mice with and without interferon-gamma stimulation.
ABSTRACT Macrophages are essential components of the innate immune system and crucial for pathogen elimination in early stages of infection. We previously observed that bone marrow-derived macrophages (BMM) from C57BL/6 mice exhibited increased killing activity against Burkholderia pseudomallei comp...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-39349 | biostudies-arrayexpress
GenomicsMitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity
Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity
PRJNA789485 | ENA
TranscriptomicsProfiling of bacterial respiratory infection, viral respiratory infection, and non-infectious illness
A pressing clinical challenge is identifying the etiologic basis of acute respiratory illness. Without reliable diagnostics, the uncertainty associated with this clinical entity leads to a significant, inappropriate use of antibacterials. Use of host peripheral blood gene expression data to classify...
ORGANISM(S): Homo sapiens 
2016-01-20 | E-GEOD-63990 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae response to nitrosative stress
Nitric oxide and NO-derived species (RNS) are defense molecules with broad antimicrobial activity. Micro-organisms have developed strategies to sense RNS and counteract their damaging effects. We used Saccharomyces cerevisiae, harbouring a deletion of YHB1 that encodes the main NO scavenger enzyme, ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-03-02 | E-MEXP-580 | biostudies-arrayexpress
TranscriptomicsMitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity
Mitochondrial dysfunction induces a strong adaptive retrograde signaling response, however many of the down-stream effectors remain to be discovered. Here, we studied the shared transcriptional responses to three different mitochondrial respiratory chain inhibitors in human primary skin fibroblasts ...
ORGANISM(S): Homo sapiens 
2022-02-25 | GSE191034 | GEO
TranscriptomicsTranscription profiling of S. cerevisiae treated with absence of oxygen or depletion of ATP to investigate control of glycolytic enzyme fluxes
Metabolic fluxes may be regulated "hierarchically," e.g., by changes of gene expression that adjust enzyme capacities (V(max)) and/or "metabolically" by interactions of enzymes with substrates, products, or allosteric effectors. In the present study, a method is developed to dissect the hierarchical...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-9232 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human Peripheral blood mononuclear cells (PBMCs) from COVID-19 patients requiring different degree of respiratory support
To identify possible deregulated pathways involved in COVID-19 severity, we analyzed the transcriptomic profiles of 59 patients affected by severe COVID-19 symptoms, comparing those who were only hospitalized and required supplemental oxygen support (N=24) with those who were also admitted to the IC...
ORGANISM(S): Homo sapiens 
2026-07-20 | E-MTAB-15584 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Moraxella catarrhalis RH4 during in vitro growth in brain heart infusion (BHI) medium
Transcriptome analysis of M. catarrhalis RH4 predicted coding sequences and clustered regularly interspaced short palindromic repeats (CRISPRs) regions. The results described in this study are further discussed in De Vries, S.P.W., van Hijum, S.A.F.T., Schueler, W., Riesbeck, K., Hays, J.P., Hermans...
ORGANISM(S): Moraxella catarrhalis RH4 
2010-05-07 | E-GEOD-21632 | biostudies-arrayexpress
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