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MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
TranscriptomicsGene expression signatures of symptomatic respiratory viral infection in adults
Diagnosis of acute respiratory viral infection is currently based on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis. We used microarrays to capture p...
ORGANISM(S): Homo sapiens 
2009-08-06 | E-GEOD-17156 | biostudies-arrayexpress
ProteomicsUninfected and human respiratory syncytial virus (RSV)-infected A549 cells, analysed using bottom-up mass spectrometry
Proteomic data from uninfected and human respiratory syncytial virus (RSV) infected A549 cells (24h post infection; four biological replicate sets). Data is related to the fractionation-free workflow described in Dave et al. (2014) (PMID: 25106423). Data is processed using MaxQuant (version 1.3.0.5)...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Respiratory Syncytial Virus A2 (ncbitaxon:11259) 
2016-08-08 | MSV000080032 | MassIVE
ProteomicsUninfected and human respiratory syncytial virus (RSV)-infected A549 cells, analysed using in-solution protein IEF followed by bottom-up mass spectrometry
Proteomic data from uninfected and human respiratory syncytial virus (RSV)-infected A549 cells (24h post infection; five paired biological replicate sets). Data is related to the in-solution protein IEF workflow described in Dave et al. (2014) (PMID: 25106423). Data processed using MaxQuant (version...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Respiratory Syncytial Virus A2 (ncbitaxon:11259) 
2016-01-12 | MSV000079453 | MassIVE
TranscriptomicsTranscription profiling of lung and bronchial lymph node from mice infected with Respiratory Syncytial Virus (RSV)
Transcriptional responses in lungs of mice infected with Respiratory Syncytial Virus (RSV) were compared to a control and mock infections
ORGANISM(S): Mus musculus 
2007-04-17 | E-TABM-221 | biostudies-arrayexpress
ProteomicsBovine Respiratory Disease Complex
Bovine respiratory epithelial cells have different susceptibility to bovine respiratory syncytial virus infection. The cells derived from the lower respiratory tract were significantly more susceptible to the virus than those derived from the upper respiratory tract. Pre-infection with virus of lowe...
ORGANISM(S): Bos Taurus 
2020-07-28 | PXD019509 | JPOST Repository
TranscriptomicsDC response to Respiratory syncytial virus from adult peripheral and cord blood
Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality. Previous studies have suggested that T cell responses may contribute to RSV immunopathology, which could be driven by dendritic cells (DCs). DCs are productively infected by RSV, and during RSV infections, there is an inc...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-24132 | biostudies-arrayexpress
TranscriptomicsBlood mRNA profiling to support prognosis of disease severity in respiratory syncytial virus infected infants
In this study we investigated whether there exists a genomic signature that can accurately predict the course of a respiratory syncytial virus (RSV) infection in hospitalized young infants. We used early blood microarray transcriptome profiles from 39 infants that were followed until recovery and of...
ORGANISM(S): Homo sapiens 
2016-11-11 | E-MTAB-5195 | biostudies-arrayexpress
GenomicsRespiratory syncytial virus
Respiratory syncytial virus Genome sequencing
PRJNA1050228 | ENA
GenomicsRespiratory syncytial virus
Respiratory syncytial virus Genome sequencing and assembly
PRJNA1419834 | ENA
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