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UnknownRandomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma.
Not available
S-EPMC4981979 | biostudies-literature
UnknownAkt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.
Not available
S-EPMC4384335 | biostudies-literature
TranscriptomicsType-1-cytokines synergize with oncogene inhibition to induce tumor growth arrest
Both targeted inhibition of oncogenic driver mutations and immune-based therapies show efficacy in treatment of patients with metastatic cancer but responses are either short-lived or incompletely effective. Oncogene inhibition can augment the efficacy of immune-based therapy but mechanisms by which...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-62249 | biostudies-arrayexpress
GenomicsStretch-Enhancers Delineate Disease-Associated Regulatory Nodes in T Cells
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60482 | biostudies-arrayexpress
UnknownT helper 17 cells promote cytotoxic T cell activation in tumor immunity.
Not available
S-EPMC2787786 | biostudies-literature
UnknownDefinitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation.
Not available
S-EPMC7688003 | biostudies-literature
UnknownIdentification of the genomic insertion site of Pmel-1 TCR α and β transgenes by next-generation sequencing.
Not available
S-EPMC4020793 | biostudies-literature
TranscriptomicsIL-12 induces myeloid cells in situ to cross-present antigen
Myeloid-derived cells comprising the tumor stroma represent a heterogeneous population of cells critical to the structure, function and growth of established cancers. We have recently found that engineering tumor-specific CD8+ T cells to secrete IL-12 (IL-12TD) can lead to striking improvements in T...
ORGANISM(S): Mus musculus 
2012-04-22 | E-GEOD-29164 | biostudies-arrayexpress
UnknownFas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.
Not available
S-EPMC5196435 | biostudies-literature
GenomicsBach2 represses effector programmes to stabilize Treg-mediated immune homeostasis
Through their functional diversification, CD4+ T cells play key roles in both driving and constraining immune-mediated pathology. Transcription factors are critical in the generation and maintenance of cellular diversity and negative regulators antagonistic to alternate fates often act in conjunctio...
ORGANISM(S): Mus musculus 
2013-06-27 | E-GEOD-45975 | biostudies-arrayexpress
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