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MetabolomicsRetinal ganglion cells lipid profiling
Not available
ORGANISM(S): Mus musculus 
ST001105 | MetabolomicsWorkbench
TranscriptomicsSingle cell RNA sequencing of stem cell-derived retinal ganglion cells
We used human embryonic stem cell-derived retinal ganglion cells (RGCs) to characterize the transcriptome of 1,174 cells at the single cell level. The human embryonic stem cell line BRN3B-mCherry A81-H7 was differentiated to RGCs using a guided differentiation approach. Cells were harvested at day 3...
ORGANISM(S): Homo sapiens 
2017-10-07 | E-MTAB-6108 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression changes in rat retinal ganglion cells after experimental glaucoma
Goals of the study: 1. Assess the gene expression profile in rat RGC after experimental IOP elevation to elucidate the molecular mechanisms of RGC death. 2. Identify potentially novel genes and pathways that may contribute to RGC death in glaucoma. Background: Glaucoma is a neurodegenerative diseas...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-12596 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse developing retinal ganglion and amacrine cells reveals molecular heterogeneity of
During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types. As these different cell types are born, they progress from newly specified cells to fully differentiated neurons and glia. In order to defi...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9812 | biostudies-arrayexpress
ProteomicsRetinal proteomic profiling in the course of experimental glaucoma
Intraocular pressure was elevated through episkleral vein occlusion by thermic cauterization of SD rats. Animals were further sacrificed after different periods of elevated IOP and the retinal proteins were investigated for alterations regarding the relative protein level in this experimental model ...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081757 | MassIVE
ProteomicsInvestigating Autophagy Disruption Induces Neurodegeneration in Glaucoma OPTN(E50K) Retinal Ganglion Cells
Retinal ganglion cells (RGCs) are the sole projection neurons that connect the eye with the brain, and the degeneration of these cells in diseases such as glaucoma results in vision loss or blindness. Similar to other neurons throughout the central nervous system, RGCs are postmitotic and therefore ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033173 | Pride
Autophagy Human pluripotent stem cell Retinal ganglion cells 
TranscriptomicsSubcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Laser capture microdissection (LCM) was used...
ORGANISM(S): Xenopus laevis 
2010-11-23 | E-GEOD-25166 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression by Set-beta in rat retinal ganglion cells
The goal of this experiment was to investigate the molecular mechanism of how Set-beta regulates neurite growth. Set-betaM-bM-^@M-^Ys subcellular localization is regulated by posttranslational modifications. We found that Set-beta suppresses neurite growth of purified postnatal rat retinal ganglion ...
ORGANISM(S): Rattus norvegicus 
2014-04-30 | E-GEOD-56951 | biostudies-arrayexpress
UnknownBone Marrow-Derived Mesenchymal Stem Cells-Derived Exosomes Promote Survival of Retinal Ganglion Cells Through miRNA-Dependent Mechanisms.
Not available
S-EPMC5442835 | biostudies-literature
UnknownmiRNA Changes in Retinal Ganglion Cells after Optic Nerve Crush and Glaucomatous Damage.
Not available
S-EPMC8305746 | biostudies-literature
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