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TranscriptomicsRNA-seq of retinal organoids differentiated from hESCs carrying mutations in the RB1 gene
hESC lines carrying deleterious mutations in the RB1 gene in heterozygous and homozygous state were generated by genome-editing based on CRISPR/Cas9. Parental cell line and genome-edited cell lines were differentiated into retinal organoids for 152 days based on the Protocol published by Döpper et a...
ORGANISM(S): Homo sapiens 
2022-05-10 | E-MTAB-10331 | biostudies-arrayexpress
TranscriptomicsMosaic perturbation of transcription factors in human retinal organoid development
To begin to understand how TFs regulate retinal cell type identity in human tissues, we established a pooled loss of function (LOF) experiment based on the CROP-seq protocol in developed retinal organoids. We targeted five TFs (OTX2, NRL, CRX, VSX2, and PAX6) that are important for retinal developme...
ORGANISM(S): Homo sapiens 
2023-02-24 | E-MTAB-12622 | biostudies-arrayexpress
TranscriptomicsRNA-seq of retinal organoids derived from RPGR patient-, control- and mutation-corrected-iPSC at different developmental stages
Retinitis pigmentosa (RP) is an irreversible and inherited retinopathy. RPGR mutations are the most common causes of this disease. It remains challenging to decipher the mechanism of RPGR mutation because of the lack of appropriate study models. The substitution of patient-specific diseased retina w...
ORGANISM(S): Homo sapiens 
2020-02-01 | E-MTAB-6490 | biostudies-arrayexpress
TranscriptomicsSingle-cell chromatin accessibility atlas of human retinal organoid development
In order to provide multi-omic resolution to human retinal organoid developmental dynamics, we performed scRNA-seq and scATAC-seq from the same cell suspension across a time course (6-46 weeks) of human retinal organoid development. This data set covers all the retinal organoid scATAC-seq data gener...
ORGANISM(S): Homo sapiens 
2023-03-12 | E-MTAB-12714 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome atlas of human retinal organoid development
In order to provide multi-omic resolution to human retinal organoid developmental dynamics, we performed scRNA-seq and scATAC-seq from the same cell suspension across a time course (6-46 weeks) of human retinal organoid development. This data set covers all the retinal organoid scRNA-seq data genera...
ORGANISM(S): Homo sapiens 
2023-03-12 | E-MTAB-12715 | biostudies-arrayexpress
GenomicsMicroarray analysis of mouse retinal organoids
Microarray analysis of mouse retinal organoids
PRJNA739908 | ENA
TranscriptomicsTranscriptomics of CD29+/CD44+ cells isolated from hPSC retinal organoids reveals a cell population with retinal progenitor and Müller glia characteristics.
Müller glia play very important and diverse roles in retinal homeostasis and disease, bur very little is known of their development during human retinal embryogenesis. Since they share several markers with retinal progenitors, they are often considered as a different cell population. In this study w...
ORGANISM(S): Homo sapiens 
2023-02-21 | E-MTAB-12467 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of human pluripotent stem cell-derived RGC-enriched retinal cells generated from hESC and hiPSC retinal organoids
This study investigates the differentiation of retinal ganglion cells (RGCs) from human pluripotent stem cells (hPSCs) to optimise and characterise in-vitro RGC generation. Retinal organoids were derived from a human embryonic stem cell line (H9) and a laboratory-established human induced pluripoten...
ORGANISM(S): Homo sapiens 
2026-05-30 | E-MTAB-16297 | biostudies-arrayexpress
TranscriptomicsMolecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution
Compare single cell transcriptomes of control and USH1B patient iPSC-derived retinal organoids to elucidate disease mechanisms of Usher syndrome type IB (USH1B). USH1B patient fibroblasts were collected at Great Ormond Street Hospital (GOSH) and reprogrammed to iPSCs. Control and patient iPSCs diffe...
ORGANISM(S): Homo sapiens 
2023-03-27 | E-MTAB-11990 | biostudies-arrayexpress
ProteomicsTracing retinal progenitors cells and photoreceptors from mouse retinal organoids
Retinal organoids have become valuable 3D model for translational and developmental research. The knowledge of the limitations of the system ensures its sensible use. All retinal cell types originate from the differentiation of retinal progenitor cells. The properties of retinal progenitors in 3D cu...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-14 | PXD039309 | Pride
Retinal organoid Mouse embryonic stem cells Retinal progenitor cells 
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