Retinal pigment epithelium

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Transcriptomics (9688)
Unknown (2352)
Genomics (1710)
Proteomics (349)
Metabolomics (108)
Other (25)
Multiomics (4)
Genomic (3)
Methylation profiling (2)
Models (1)

Organisms

Homo sapiens (4254)
Mus musculus (2378)
Saccharomyces cerevisiae (379)
Drosophila melanogaster (332)
Arabidopsis thaliana (308)
Rattus norvegicus (271)
Danio rerio (163)
Caenorhabditis elegans (128)
Sus scrofa (104)
Schizosaccharomyces pombe (96)
Gallus gallus (82)
Bos taurus (78)
Escherichia coli (74)
Thermus thermophilus HB8 (69)
Candida albicans (67)
Salmo salar (54)
Salmonella enterica subsp. enterica serovar Typhimurium (50)
Staphylococcus aureus (45)
Apis mellifera (41)
Mycobacterium tuberculosis (40)
Zea mays (35)
Oncorhynchus mykiss (35)
Glycine max (33)
Rhizobium leguminosarum (30)
Rattus rattus (27)
Triticum aestivum (25)
Canis lupus familiaris (25)
Ovis aries (24)
Oryza sativa Japonica Group (24)
Pseudomonas aeruginosa (24)

Organisms

Homo sapiens (118)
Mus musculus (100)
Danio rerio (14)
Gallus gallus (7)
Macaca mulatta (4)
Rattus norvegicus (3)
unidentified (2)
Macaca fascicularis (2)
Oryctolagus cuniculus (2)
Ictidomys tridecemlineatus (1)
Nothobranchius furzeri (1)
Caenorhabditis elegans (1)

Repository

biostudies-arrayexpress (10354)
EGA (574)
ENA (310)
geo (240)
MassIVE (171)
MetaboLights (106)
pride (53)
jPOST (38)
iProX (20)
PanoramaPublic (15)
LINCS (11)
PAXDB (10)
GPMDB (7)
EVA (6)
dbGaP (3)
ExpressionAtlas (2)
GNPS (2)
Cell Collective (1)
PeptideAtlas (1)

Tissue

Retinal pigment epithelium cell (14)
Epithelial cell (13)
Retina (9)
Retinal pigment epithelial cell (9)
Cell culture (7)
Retinal pigment epithelium (7)
Retinal pigment epithelium cell line (7)
Choroid (3)
Embryonic stem cell (2)
Iris (2)
Vitreous humor (2)
Retina with retinal pigment epithelium (1)
Whole organism (1)
Female Reproductive System (1)
Choroidal cell of the eye (1)
Ciliary body (1)
Embryo (1)
Heart (1)
Kidney (1)
Liver (1)
Neural retina (1)
Pluripotent stem cell (1)
Spleen (1)
Stem cell (1)
Whole body (1)

Disease

Normal (75)
Breast cancer (10)
Neuroblastoma (8)
Colorectal cancer (6)
Chronic lymphocytic leukemia (6)
Glioblastoma (6)
Melanoma (5)
Reference (4)
Adenocarcinoma (4)
Acute myeloid leukemia (4)
Rheumatoid arthritis (3)
Colon cancer (3)
Pre-diabetic (3)
NA (3)
Prostate cancer (3)
Not applicable (3)
ACUTE MYELOID LEUKEMIA (2)
Squamous Cell Carcinoma (2)
Primary tumor (2)
Malignant melanoma (2)
Leukemia (2)
Hyperglycaemic (2)
Colon adenocarcinoma (2)
Chronic myeloid leukemia (2)
Head and neck squamous cell carcinoma (2)
Cancer (2)
Mammary tumor (2)
Acute promyelocytic leukemia (2)
Gastric cancer (2)
No disease (2)

Technology Type

Illumina HiSeq 2000 (23)
Illumina MiSeq (13)
Illumina HiSeq 2500, ILLUMINA (11)
ILLUMINA, Illumina HiSeq 2500 (7)
Illumina HiSeq 2500 (4)
Illumina HiSeq 2000, ILLUMINA (3)
Illumina Genome Analyzer II (3)
Illumina MiSeq, ILLUMINA (2)
Illumina HiSeq 2500, ILLUMINA, Illumina HiSeq 2000 (2)
ILLUMINA, Low Pass Whole Genome Sequencing (LP-WGS), Illumina NovaSeq 6000, Illumina Genome Analyzer II, SNP array (1)
Illumina MiSeq, HiSeq X Ten, NextSeq 500, Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
Illumina CytoSNP 12 bead array, nanostring (1)
ILLUMINA, Illumina HiSeq 1000 (1)
Illumina humanomniexpress-24-v1-1, humanomniexpress-24-v1-1, Illumina HumanOmniExpress-12-v1-0, Illumina HumanOmni1-Quad_v1-0, HumanOmni25-8v1-2_A1, HumanOmniExpress-12-v1-0 (1)
Illumina Multi-EthnicGlobal_A1 (1)
Illumina InfiniumCoreExome-24v1-1_A (1)
SNP6, ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500, ILLUMINA, NextSeq 500 (1)
ILLUMINA, HiSeq X Ten (1)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 4000, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500, ILLUMINA, Illumina MiSeq, NextSeq 500 (1)
ILLUMINA, Illumina HiSeq 2500, HiSeq X Ten (1)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 4000, ILLUMINA (1)
Illumina HumanCoreExome-12v1-0_A and HumanCoreExome-24v1-0_A, Illumina Human670-QuadCustom_v1_A (1)
Illumina HumanMethylation450 (1)
Illumina HumanMethylation 450K (1)
Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
Affymetrix SNP 6.0 (1)

Instrument Platform

Illumina NovaSeq 6000 (294)
Illumina HiSeq 2500 (244)
Illumina HiSeq 2000 (227)
NextSeq 500 (222)
Illumina HiSeq 4000 (160)
Illumina MiSeq (73)
NextSeq 550 (68)
Scanning hardware (41)
Illumina Genome Analyzer II (39)
NextSeq 2000 (38)
Illumina NovaSeq X (36)
Illumina HiSeq 1500 (22)
Axon GenePix 4000B scanning hardware (21)
Illumina Genome Analyzer IIx (20)
GenePix 4000B [Axon Instruments] (19)
GenePix 4000A [Axon Instruments] (18)
Axon GenePix 4000A scanning hardware (17)
Axon- GenePix4000B (15)
Illumina HiSeq 3000 (15)
ScanArray Express HT (13)
DNBSEQ-G400 (13)
Illumina HiSeq 1000 (12)
G2565BA DNA microarray scanner [Agilent] (10)
ArrayWoRx Biochip Reader [Applied Precision] (9)
Other (9)
418 [Affymetrix] (9)
Variable Atmosphere Incubator (9)
G2565AA DNA microarray scanner [Agilent] (8)
NA (8)
Agilent 2100 Bioanalyzer (7)

Publication Date

2010 (1565)
2013 (1179)
2014 (1095)
2012 (1004)
2015 (950)
2011 (866)
2016 (649)
2008 (506)
2009 (436)
2007 (301)
2021 (250)
2026 (232)
2025 (230)
2022 (230)
2024 (214)
2023 (214)
2020 (194)
2017 (185)
2005 (166)
2019 (155)
2006 (149)
2018 (137)
2004 (81)
2003 (17)
2002 (6)
2001 (2)

UNIPROT ID/AC

1433S_HUMAN (3)
ACTB_HUMAN (3)
ACTG_HUMAN (3)
APMAP_HUMAN (3)
APOC3_HUMAN (3)
AT1A1_HUMAN (3)
B2MG_HUMAN (3)
BLVRB_HUMAN (3)
BTD_HUMAN (3)
C4BPA_HUMAN (3)
C9J9W1_HUMAN (3)
CATA_HUMAN (3)
CD44_HUMAN (3)
CHM4A_HUMAN (3)
CLUS_HUMAN (3)
CO3_HUMAN (3)
CUL1_HUMAN (3)
CYTC_HUMAN (3)
DSG2_HUMAN (3)
EMC1_HUMAN (3)
FBLN1_HUMAN (3)
FBLN3_HUMAN (3)
FKB15_HUMAN (3)
G3P_HUMAN (3)
GALE_HUMAN (3)
GELS_HUMAN (3)
GGH_HUMAN (3)
GOGA4_HUMAN (3)
HOOK1_HUMAN (3)
HSPB1_HUMAN (3)

ENSEMBL ID

ENSG00000147251 (1)
ENSG00000170477 (1)
ENSG00000204131 (1)
ENSG00000229353 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:30769 (27)
CHEBI:16919 (25)
CHEBI:15891 (24)
CHEBI:15428 (24)
CHEBI:16737 (23)
CHEBI:32816 (21)
CHEBI:17268 (21)
CHEBI:27266 (19)
CHEBI:15971 (19)
CHEBI:16015 (19)
CHEBI:24898 (18)
CHEBI:16958 (18)
CHEBI:18012 (18)
CHEBI:30915 (18)
CHEBI:15354 (18)
CHEBI:17368 (18)
CHEBI:26271 (17)
CHEBI:28300 (17)
CHEBI:17754 (17)
CHEBI:6650 (17)
CHEBI:16977 (17)
CHEBI:17596 (17)
CHEBI:25017 (16)
CHEBI:30794 (16)
CHEBI:28044 (16)
CHEBI:18237 (16)
CHEBI:18050 (16)
CHEBI:15741 (16)
CHEBI:17203 (16)
CHEBI:22653 (16)

Metabolite Name

Creatinine (18)
Creatine (17)
Taurine (16)
Hypoxanthine (15)
Glycine (12)
Myo-inositol (12)
L-Histidine (12)
Choline (12)
L-Glutamine (12)
Isoleucine (12)
Leucine (11)
Creatine (11)
Beta-alanine (11)
Valine (11)
L-Arginine (11)
Citric acid (11)
Alanine (11)
L-Tyrosine (11)
Inosine (11)
Glycine (10)
Taurine (10)
L-alanine (10)
Betaine (10)
Ornithine (10)
L-Proline (10)
Phenylalanine (10)
Glutamine (10)
Adenine (10)
Glycerophosphocholine (10)
Tryptophan (10)

First Public Date

2026 (62)
2025 (35)
2024 (34)
2021 (26)
2020 (26)
2022 (25)
2023 (24)
2014 (23)
2019 (19)
2015 (11)
2017 (9)
2018 (6)
2016 (6)
2013 (4)

Modification

4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (5920)
RNA-seq of coding RNA (1247)
ChIP-seq (635)
Unknown experiment type (318)
Comparative genomic hybridization by array (229)
ChIP-chip by tiling array (211)
RNA-seq of coding RNA from single cells (208)
Other (198)
RNA-seq of non coding RNA (180)
ChIP-chip by array (141)
Methylation profiling by array (130)
Methylation profiling by high throughput sequencing (108)
Transcription profiling by tiling array (86)
MicroRNA profiling by array (75)
RNA-seq of total RNA (70)
DNA-seq (56)
Transcription profiling by RT-PCR (54)
Proteomic profiling by array (42)
Cell line - High-throughput sequencing (39)
ATAC-seq (28)
Genotyping by array (26)
Animal - High-throughput sequencing (25)
High-throughput sequencing (22)
Spatial transcriptomics by high-throughput sequencing (18)
CLIP-seq (16)
MicroRNA profiling by high throughput sequencing (16)
RIP-seq (16)
Human - High-throughput sequencing (15)
CUT&RUN (14)
Ribo-seq (13)

Release Date

2010 (1590)
2013 (1228)
2014 (1169)
2012 (1053)
2015 (1028)
2011 (903)
2016 (740)
2008 (522)
2009 (468)
2021 (407)
2022 (406)
2020 (376)
2023 (367)
2025 (363)
2007 (315)
2024 (311)
2017 (283)
2019 (281)
2018 (249)
2026 (178)
2005 (177)
2006 (157)
2004 (90)
2003 (19)
2002 (12)
2001 (3)
1998 (3)
1999 (2)
1997 (1)
1996 (1)

Lab affiliation

Head of the Curie Institute Mass Spectrometry Platform (2)
Proteomics core facility, Biomedical Research Institute, Seoul National University Hospital (2)
1Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD (1)
1Department of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. (1)
Aarhus University (1)
Associate Professor, Department of Biochemistry and Molecular Medicine, West Virginia University (1)
Baxter Laboratory for Stem Cell Biology Department of Microbiology & Immunology Stanford University School of Medicine 269 Campus Drive CCSR 3205b Stanford, CA 94305-5175 (1)
Baxter Laboratory for Stem Cell Biology Department of Microbiology & Immunology Stanford University School of Medicine (1)
Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry Department of Clinical Chemistry, University Medical Center Goettingen (1)
College of Medicine University of Arkansas for Medical Science (1)
Dame Kate Campbell Fellow Department of Surgery| Melbourne Medical School Department of Anatomy and Physiology| School of Biomedical Sciences Faculty of Medicine, Dentistry and Health Sciences Medical Building (#181), Grattan Street The University of Melbourne, Victoria 3010 Australia P: +61 3 9035 5464 E: apebay@unimelb.edu.au W: https://medicine.unimelb.edu.au/school-structure/surgery W: https://biomedicalsciences.unimelb.edu.au/departments/anatomy-and-physiology (1)
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, VIC, Australia (1)
Department of Biological Sciences University of Delaware Newark, DE, USA. (1)
Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 (1)
Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic (1)
Department of Medicine, section of Physiology and Biochemistry, University of Perugia (1)
Department of Ophthalmology and Visual Sciences, Case Western reserve University,Cleveland,OH,USA (1)
Department of Ophthalmology, University of California, Irvine, CA 92697 (1)
Department of Ophthalmology, Johns Hopkins University School of Medicine (1)
Department of Opthalmology, Boston Children's Hospital, Harvard Medical School (1)
Department of Pathology, Johns Hopkins Medical School, USA (1)
Department of Pediatrics and Genetics, Stanford University, Stanford, CA 94305, USA (1)
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo (1)
Department of Pharmacology, School of Medicine, Case Western Reserve University,cleveland,OH,USA (1)
Department of Radiation Oncology, University of Texas Health Science Center at San Antonio (1)
Director UAB Proteomics Facility (1)
Eye & Vison Health, Flinders University School of Medicine Flinders Medical Center Flinders University Australia (1)
IRCCS Fondazione Bietti, Rome (1)
Institute for Ophthalmic Research Centre for Ophthalmology, University of Tübingen, Germany (1)
Institute for Ophthalmic Research, University Clinics Tuebingen (1)

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Transcription profiling of zebrafish embryonic retinal pigment epithelium in vivo

Eye development and photoreceptor maintenance requires the retinal pigment epithelium (RPE), a thin layer of cells that underlies the neural retina. Despite its importance, RPE development has not been studied by a genomic approach. A microarray expression profiling methodology was established in th...

ORGANISM(S): Danio rerio

2008-06-13 | E-GEOD-5048 | biostudies-arrayexpress

cryo-EM study of bovine retinal pigment epithelium cell lysate

This is the proteomic analysis data of bovine retinal pigment epithelium cell lysate subjected to cryo-EM study.

ORGANISM(S): Bos taurus (Bovine)

2023-01-02 | PXD037186 | Pride

The proteome of normal human iris, ciliary body, retinal pigment epithelium, and choroid

The iris is a fine structure that controls the amount of light that enters the eye. The ciliary body controls the shape of the lens and produces aqueous humor. The retinal pigment epithelium and choroid (RPE/choroid) are essential in supporting the retina and absorbing light energy that enters the e...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-11-29 | MSV000081766 | MassIVE

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

To identify disease-specific transcriptional programs in retinal pigment epithelium (RPE) cells, fibroblasts from 43 patients with geographic atrophy (GA) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into RPE and compared to those from 36 healthy individu...

ORGANISM(S): Homo sapiens

2022-06-20 | E-MTAB-11642 | biostudies-arrayexpress

Transcriptome Analysis and Molecular Signature of Human Retinal Pigment Epithelium

The retinal pigment epithelium (RPE) is a polarized cell layer that is critical for photoreceptor function and survival. Itâ€™s unique relationship to the photoreceptors and its specific physiology makes the RPE a critical determinant of human vision. Therefore we performed global expression profil...

ORGANISM(S): Homo sapiens

2010-04-28 | E-GEOD-18811 | biostudies-arrayexpress

Expression data from human induced pluripotent stem cells derived retinal pigment epithelium (hiPSC-RPE)

We generated hiPSCs from patients fibloblast with retinitis pigmentosa (RP) using retrovirus and Sendai virus vectors, which we differentiated into hiPSC derived retinal pigment epithelium using two different methods (SDIA and SFEB methods). We investigated whether these hiPSC-RPE colonies, which we...

ORGANISM(S): Homo sapiens

2014-11-03 | E-GEOD-50738 | biostudies-arrayexpress

Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina

Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the loss of the retinal pigment epithelium (RPE) and photoreceptors and/or retinal and choroidal angiogenesis. Here we use AMD patient specific RPE cells with the Y402H high-risk polymorphism in the comp...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2022-01-21 | MSV000088713 | MassIVE

Whole genome methylation profiling of the retinal pigment epithelium of individuals with age-related macular degeneration

Illumina Infinium HumanMethylation450 BeadChip data from genomic DNA of retinal pigment epithelium from Age-related Macular Degeneration patients or age-matched controls.

ORGANISM(S): Homo sapiens

2019-08-01 | E-MTAB-7183 | biostudies-arrayexpress

RNA-seq of retinal pigment epithelium (RPE) derived from human induced pluripotent stem cells (iPSCs): healthy control and USH1B patient iPSCs

Compare transcriptomes of control and USH1B patient iPSC-derived retinal pigment epithelium (RPE) to elucidate disease mechanisms of Usher syndrome type IB (USH1B). USH1B patient fibroblasts were collected at Great Ormond Street Hospital (GOSH) and reprogrammed to iPSCs. Control and patient iPSCs di...

ORGANISM(S): Homo sapiens

2023-08-22 | E-MTAB-12165 | biostudies-arrayexpress

Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis

To explore the epigenetic contribution to retinal development, we generated conditional knockout alleles of DNA methytransferase-1 (Dnmt1) mediated by Rx-Cre in mice. The results demonstrate a unique function of DNMT1-mediated DNA methylation in controlling RPE apicobasal polarity and neural retina...

ORGANISM(S): Mus musculus

2013-01-31 | E-GEOD-43951 | biostudies-arrayexpress

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