Retinal pigment epithelium (rpe)

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Transcriptomics (9669)
Genomics (1645)
Unknown (1588)
Proteomics (323)
Metabolomics (107)
Other (22)
Multiomics (4)
Models (1)
Genomic (1)
Methylation profiling (1)

Organisms

Homo sapiens (4238)
Mus musculus (2364)
Saccharomyces cerevisiae (379)
Drosophila melanogaster (332)
Arabidopsis thaliana (308)
Rattus norvegicus (270)
Danio rerio (161)
Caenorhabditis elegans (127)
Sus scrofa (104)
Schizosaccharomyces pombe (96)
Gallus gallus (81)
Bos taurus (78)
Escherichia coli (74)
Thermus thermophilus HB8 (69)
Candida albicans (67)
Salmo salar (54)
Salmonella enterica subsp. enterica serovar Typhimurium (50)
Staphylococcus aureus (45)
Apis mellifera (41)
Mycobacterium tuberculosis (40)
Zea mays (35)
Oncorhynchus mykiss (35)
Glycine max (33)
Rhizobium leguminosarum (30)
Rattus rattus (27)
Triticum aestivum (25)
Canis lupus familiaris (25)
Ovis aries (24)
Oryza sativa Japonica Group (24)
Pseudomonas aeruginosa (24)

Organisms

Homo sapiens (99)
Mus musculus (91)
Danio rerio (12)
Gallus gallus (6)
Macaca mulatta (3)
Rattus norvegicus (3)
unidentified (2)
Macaca fascicularis (2)
Ictidomys tridecemlineatus (1)
Nothobranchius furzeri (1)

Repository

biostudies-arrayexpress (10364)
EGA (571)
ENA (254)
geo (204)
MassIVE (171)
MetaboLights (106)
jPOST (38)
pride (30)
iProX (16)
PanoramaPublic (15)
LINCS (11)
PAXDB (10)
GPMDB (7)
EVA (6)
Cell Collective (1)
dbGaP (1)
GNPS (1)
PeptideAtlas (1)

Tissue

Retinal pigment epithelium cell (9)
Epithelial cell (7)
Retina (6)
Retinal pigment epithelial cell (6)
Retinal pigment epithelium cell line (5)
Retinal pigment epithelium (4)
Cell culture (3)
Embryonic stem cell (2)
Female Reproductive System (1)
Choroid (1)
Ciliary body (1)
Embryo (1)
Iris (1)
Kidney (1)
Liver (1)
Neural retina (1)
Pluripotent stem cell (1)
Spleen (1)
Stem cell (1)
Vitreous humor (1)

Disease

Normal (75)
Breast cancer (10)
Neuroblastoma (8)
Colorectal cancer (6)
Chronic lymphocytic leukemia (6)
Glioblastoma (6)
Melanoma (5)
Reference (4)
Adenocarcinoma (4)
Acute myeloid leukemia (4)
Rheumatoid arthritis (3)
Colon cancer (3)
Pre-diabetic (3)
NA (3)
Prostate cancer (3)
Not applicable (3)
ACUTE MYELOID LEUKEMIA (2)
Squamous Cell Carcinoma (2)
Primary tumor (2)
Malignant melanoma (2)
Leukemia (2)
Hyperglycaemic (2)
Colon adenocarcinoma (2)
Chronic myeloid leukemia (2)
Head and neck squamous cell carcinoma (2)
Cancer (2)
Mammary tumor (2)
Acute promyelocytic leukemia (2)
Gastric cancer (2)
No disease (2)

Technology Type

Illumina HiSeq 2000 (23)
Illumina MiSeq (13)
Illumina HiSeq 2500, ILLUMINA (11)
ILLUMINA, Illumina HiSeq 2500 (7)
Illumina HiSeq 2500 (4)
Illumina HiSeq 2000, ILLUMINA (3)
Illumina Genome Analyzer II (3)
Illumina MiSeq, ILLUMINA (2)
Illumina HiSeq 2500, ILLUMINA, Illumina HiSeq 2000 (2)
ILLUMINA, Low Pass Whole Genome Sequencing (LP-WGS), Illumina NovaSeq 6000, Illumina Genome Analyzer II, SNP array (1)
Illumina MiSeq, HiSeq X Ten, NextSeq 500, Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
Illumina CytoSNP 12 bead array, nanostring (1)
ILLUMINA, Illumina HiSeq 1000 (1)
Illumina humanomniexpress-24-v1-1, humanomniexpress-24-v1-1, Illumina HumanOmniExpress-12-v1-0, Illumina HumanOmni1-Quad_v1-0, HumanOmni25-8v1-2_A1, HumanOmniExpress-12-v1-0 (1)
Illumina Multi-EthnicGlobal_A1 (1)
Illumina InfiniumCoreExome-24v1-1_A (1)
SNP6, ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500, ILLUMINA, NextSeq 500 (1)
ILLUMINA, HiSeq X Ten (1)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 4000, Illumina HiSeq 2500 (1)
Illumina HiSeq 2500, ILLUMINA, Illumina MiSeq, NextSeq 500 (1)
ILLUMINA, Illumina HiSeq 2500, HiSeq X Ten (1)
HiSeq X Ten, ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 4000, ILLUMINA (1)
Illumina HumanCoreExome-12v1-0_A and HumanCoreExome-24v1-0_A, Illumina Human670-QuadCustom_v1_A (1)
Illumina HumanMethylation450 (1)
Illumina HumanMethylation 450K (1)
Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
Affymetrix SNP 6.0 (1)

Instrument Platform

Illumina NovaSeq 6000 (301)
Illumina HiSeq 2500 (244)
Illumina HiSeq 2000 (227)
NextSeq 500 (222)
Illumina HiSeq 4000 (160)
Illumina MiSeq (73)
NextSeq 550 (68)
Scanning hardware (41)
Illumina Genome Analyzer II (39)
Illumina NovaSeq X (39)
NextSeq 2000 (38)
Illumina HiSeq 1500 (22)
Axon GenePix 4000B scanning hardware (21)
Illumina Genome Analyzer IIx (20)
GenePix 4000B [Axon Instruments] (19)
GenePix 4000A [Axon Instruments] (18)
Axon GenePix 4000A scanning hardware (17)
Axon- GenePix4000B (15)
Illumina HiSeq 3000 (15)
DNBSEQ-G400 (14)
ScanArray Express HT (13)
N/A (13)
Illumina HiSeq 1000 (12)
G2565BA DNA microarray scanner [Agilent] (10)
ArrayWoRx Biochip Reader [Applied Precision] (9)
Other (9)
418 [Affymetrix] (9)
Variable Atmosphere Incubator (9)
G2565AA DNA microarray scanner [Agilent] (8)
NA (8)

Publication Date

2010 (1564)
2013 (1178)
2014 (1094)
2012 (1004)
2015 (944)
2011 (866)
2016 (647)
2008 (505)
2009 (435)
2007 (300)
2021 (246)
2026 (238)
2025 (225)
2022 (225)
2023 (206)
2024 (204)
2020 (190)
2017 (184)
2005 (166)
2019 (150)
2006 (149)
2018 (135)
2004 (81)
2003 (17)
2002 (6)
2001 (2)

UNIPROT ID/AC

1433S_HUMAN (3)
ACTB_HUMAN (3)
ACTG_HUMAN (3)
APMAP_HUMAN (3)
APOC3_HUMAN (3)
AT1A1_HUMAN (3)
B2MG_HUMAN (3)
BLVRB_HUMAN (3)
BTD_HUMAN (3)
C4BPA_HUMAN (3)
C9J9W1_HUMAN (3)
CATA_HUMAN (3)
CD44_HUMAN (3)
CHM4A_HUMAN (3)
CLUS_HUMAN (3)
CO3_HUMAN (3)
CUL1_HUMAN (3)
CYTC_HUMAN (3)
DSG2_HUMAN (3)
EMC1_HUMAN (3)
FBLN1_HUMAN (3)
FBLN3_HUMAN (3)
FKB15_HUMAN (3)
G3P_HUMAN (3)
GALE_HUMAN (3)
GELS_HUMAN (3)
GGH_HUMAN (3)
GOGA4_HUMAN (3)
HOOK1_HUMAN (3)
HSPB1_HUMAN (3)

ENSEMBL ID

ENSG00000147251 (1)
ENSG00000170477 (1)
ENSG00000204131 (1)
ENSG00000229353 (1)
ENSG00000247315 (1)

CHEBI ID

CHEBI:30769 (27)
CHEBI:16919 (25)
CHEBI:15428 (24)
CHEBI:15891 (24)
CHEBI:16737 (23)
CHEBI:32816 (21)
CHEBI:17268 (21)
CHEBI:27266 (19)
CHEBI:15971 (19)
CHEBI:16015 (19)
CHEBI:15354 (18)
CHEBI:16958 (18)
CHEBI:24898 (18)
CHEBI:18012 (18)
CHEBI:30915 (18)
CHEBI:17368 (18)
CHEBI:16977 (17)
CHEBI:17754 (17)
CHEBI:28300 (17)
CHEBI:26271 (17)
CHEBI:6650 (17)
CHEBI:17596 (17)
CHEBI:30794 (16)
CHEBI:16449 (16)
CHEBI:25017 (16)
CHEBI:18050 (16)
CHEBI:22653 (16)
CHEBI:27897 (16)
CHEBI:17203 (16)
CHEBI:15741 (16)

Metabolite Name

Creatinine (20)
Creatine (17)
Taurine (16)
Hypoxanthine (14)
L-Histidine (13)
L-Glutamine (13)
Choline (13)
Myo-inositol (12)
Glycine (12)
Ornithine (12)
Inosine (12)
Alanine (12)
L-Tyrosine (12)
Isoleucine (12)
L-Proline (12)
Beta-alanine (11)
Valine (11)
Creatine (11)
Glycine (11)
Glutamine (11)
L-Phenylalanine (11)
Citric acid (11)
L-Arginine (11)
Betaine (11)
Spermidine (10)
Taurine (10)
L-alanine (10)
Adenine (10)
Leucine (10)
Glycerophosphocholine (10)

First Public Date

2026 (50)
2025 (30)
2024 (30)
2014 (23)
2020 (21)
2022 (20)
2021 (20)
2023 (17)
2019 (15)
2017 (8)
2015 (7)
2018 (5)
2016 (5)
2013 (3)

Modification

4x(15)N labeled L-arginine (1)

Study type

Transcription profiling by array (5918)
RNA-seq of coding RNA (1256)
ChIP-seq (635)
Unknown experiment type (318)
Comparative genomic hybridization by array (229)
ChIP-chip by tiling array (211)
RNA-seq of coding RNA from single cells (210)
Other (198)
RNA-seq of non coding RNA (180)
ChIP-chip by array (141)
Methylation profiling by array (130)
Methylation profiling by high throughput sequencing (108)
Transcription profiling by tiling array (86)
MicroRNA profiling by array (75)
RNA-seq of total RNA (70)
DNA-seq (56)
Transcription profiling by RT-PCR (54)
Proteomic profiling by array (42)
Cell line - High-throughput sequencing (39)
ATAC-seq (28)
Genotyping by array (26)
Animal - High-throughput sequencing (25)
High-throughput sequencing (22)
Spatial transcriptomics by high-throughput sequencing (18)
CLIP-seq (16)
MicroRNA profiling by high throughput sequencing (16)
RIP-seq (16)
Human - High-throughput sequencing (15)
CUT&RUN (14)
Ribo-seq (13)

Release Date

2010 (1582)
2013 (1203)
2014 (1130)
2012 (1031)
2015 (995)
2011 (885)
2016 (712)
2008 (511)
2009 (452)
2021 (350)
2022 (334)
2007 (311)
2025 (309)
2023 (307)
2020 (304)
2024 (251)
2017 (241)
2019 (225)
2018 (195)
2026 (181)
2005 (172)
2006 (153)
2004 (85)
2003 (18)
2002 (8)
2001 (1)
1997 (1)
1996 (1)

Lab affiliation

Proteomics core facility, Biomedical Research Institute, Seoul National University Hospital (2)
1Department of Ophthalmology, Stem Cell Ocular Regenerative Medicine Center, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. (1)
Aarhus University (1)
Associate Professor, Department of Biochemistry and Molecular Medicine, West Virginia University (1)
Baxter Laboratory for Stem Cell Biology Department of Microbiology & Immunology Stanford University School of Medicine 269 Campus Drive CCSR 3205b Stanford, CA 94305-5175 (1)
Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry Department of Clinical Chemistry, University Medical Center Goettingen (1)
Dame Kate Campbell Fellow Department of Surgery| Melbourne Medical School Department of Anatomy and Physiology| School of Biomedical Sciences Faculty of Medicine, Dentistry and Health Sciences Medical Building (#181), Grattan Street The University of Melbourne, Victoria 3010 Australia P: +61 3 9035 5464 E: apebay@unimelb.edu.au W: https://medicine.unimelb.edu.au/school-structure/surgery W: https://biomedicalsciences.unimelb.edu.au/departments/anatomy-and-physiology (1)
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Sciences, La Trobe University, Melbourne, VIC, Australia (1)
Department of Biology, University of Fribourg Chemin du Musée 10, 1700 Fribourg, Switzerland T +41 26 300 8631 (1)
Department of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic (1)
Department of Ophthalmology and Visual Sciences, Case Western reserve University,Cleveland,OH,USA (1)
Department of Ophthalmology, University of California, Irvine, CA 92697 (1)
Department of Ophthalmology, Johns Hopkins University School of Medicine (1)
Department of Opthalmology, Boston Children's Hospital, Harvard Medical School (1)
Department of Pathology, Johns Hopkins Medical School, USA (1)
Department of Pediatrics and Genetics, Stanford University, Stanford, CA 94305, USA (1)
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo (1)
Department of Radiation Oncology, University of Texas Health Science Center at San Antonio (1)
Director UAB Proteomics Facility (1)
Institute of Biochemistry II, Faculty of Medicine, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany (1)
Laboratory of Neural Development and Regeneration, CIBIO Department - University of Trento Via Sommarive 9, 38123 Trento, ITALY Centre for Medical Sciences - CISMed University of Trento Via S. Maria Maddalena 1, 38122 Trento, Italy (1)
Laboratory of RNA Biology Institute of Molecular Genetics of the Czech Academy of Sciences Prague, Czechia (1)
Max Planck Institute for Multidisciplinary Sciences, Bioanalytical Mass Spectrometry Group, Göttingen, Germany University Medical Center Göttingen, Department of Clinical Chemistry, Bioanalytics Group, Göttingen, Germany (1)
Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA (1)
School of Optometry, the Hong Kong Polytechnic University, Hong Kong, China Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China Research Centre for SHARP Vision (RCSV), the Hong Kong Polytechnic University, Hong Kong, China Research Centre for Chinese Medicine (RCMI), the Hong Kong Polytechnic University, Hong Kong, China (1)
The University of Melbourne (1)
The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, Northern Ireland, UK. (1)
University of Pittsburgh School of Medicine, Ophthalmology department (1)
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, United States of America (1)

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Transcription profiling of zebrafish embryonic retinal pigment epithelium in vivo

Eye development and photoreceptor maintenance requires the retinal pigment epithelium (RPE), a thin layer of cells that underlies the neural retina. Despite its importance, RPE development has not been studied by a genomic approach. A microarray expression profiling methodology was established in th...

ORGANISM(S): Danio rerio

2008-06-13 | E-GEOD-5048 | biostudies-arrayexpress

The proteome of normal human iris, ciliary body, retinal pigment epithelium, and choroid

The iris is a fine structure that controls the amount of light that enters the eye. The ciliary body controls the shape of the lens and produces aqueous humor. The retinal pigment epithelium and choroid (RPE/choroid) are essential in supporting the retina and absorbing light energy that enters the e...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2017-11-29 | MSV000081766 | MassIVE

Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration

To identify disease-specific transcriptional programs in retinal pigment epithelium (RPE) cells, fibroblasts from 43 patients with geographic atrophy (GA) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into RPE and compared to those from 36 healthy individu...

ORGANISM(S): Homo sapiens

2022-06-20 | E-MTAB-11642 | biostudies-arrayexpress

Transcriptome Analysis and Molecular Signature of Human Retinal Pigment Epithelium

The retinal pigment epithelium (RPE) is a polarized cell layer that is critical for photoreceptor function and survival. Itâ€™s unique relationship to the photoreceptors and its specific physiology makes the RPE a critical determinant of human vision. Therefore we performed global expression profil...

ORGANISM(S): Homo sapiens

2010-04-28 | E-GEOD-18811 | biostudies-arrayexpress

Expression data from human induced pluripotent stem cells derived retinal pigment epithelium (hiPSC-RPE)

We generated hiPSCs from patients fibloblast with retinitis pigmentosa (RP) using retrovirus and Sendai virus vectors, which we differentiated into hiPSC derived retinal pigment epithelium using two different methods (SDIA and SFEB methods). We investigated whether these hiPSC-RPE colonies, which we...

ORGANISM(S): Homo sapiens

2014-11-03 | E-GEOD-50738 | biostudies-arrayexpress

Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina

Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the loss of the retinal pigment epithelium (RPE) and photoreceptors and/or retinal and choroidal angiogenesis. Here we use AMD patient specific RPE cells with the Y402H high-risk polymorphism in the comp...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2022-01-21 | MSV000088713 | MassIVE

Expression profiling of the retinal pigment epithelium in zebrafish smarca4 mutant

Purpose: The purpose of this study was to develop a framework for analyzing RPE expression profiles from zebrafish eye mutants. Methods: The fish model we used was smarca4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), a retinal dystrophic muta...

ORGANISM(S): Danio rerio

2014-01-03 | E-GEOD-50241 | biostudies-arrayexpress

Transcription profiling of mouse ark adapted and light damaged BALBc (albino) retinal pigmented epithelium

Transcriptional profiles were compared between dark adapted and light damaged BALBc (albino) mouse RPE. Experiment Overall Design: BALBc mice were dark adapted for one week. To produce light damage a subset of the mice were then exposed to 6,000 lux white fluorescent light for 1.5 hours. RPEs were c...

ORGANISM(S): Mus musculus

2008-10-26 | E-GEOD-13074 | biostudies-arrayexpress

Pigment Epithelium Derived Factor (PEDF) secreted from iPSC derived-RPE facilitates apoptotic causes cell death, not the differentiation, of iPSCs

We show that Retinal pigment epithelium (RPE) secreted-factor, pigment epithelium derived factor (PEDF) secreted/derived from primary or iPSC-derived retinal pigment epithelium (RPE)RPE, dramatically inhibitsed the cell growth of iPSCs. PEDF was detected abundantly in culture supernatant media of pr...

ORGANISM(S): Homo sapiens

2013-01-03 | E-GEOD-43257 | biostudies-arrayexpress

Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells

Retinal pigment epithelium (RPE) cells can be obtained through in vitro differentiation of both embryonic stem cell (ESC) and induced pluripotent stem cells (iPSC) for cell replacement therapy. We have previously identified 87 signature genes relevant to RPE cell differentiation and function through...

ORGANISM(S): Homo sapiens

2012-08-01 | E-GEOD-37686 | biostudies-arrayexpress

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