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TranscriptomicsTranscription profiling of human donor-matched retinal and choroidal vascular endothelial cells
Consistent with clinical observations that posterior uveitis frequently involves the retinal vasculature and recent recognition of vascular heterogeneity, we hypothesized that retinal vascular endothelium was a cell population of unique molecular phenotype. Donor-matched cultures of primary retinal ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7850 | biostudies-arrayexpress
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
OtherProteins involved in focal adhesion signaling pathways are differentially regulated in experimental branch retinal vein occlusion.
Data from ProteomeXchange, PXD ID: PXD001800. File: 6H_02.mzml. Published as part of Exp Eye Res. 2015 Jun 15;138:87-95 . From the Abstract: {{i}} Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the condition remain largely unelucidate...
ORGANISM(S): Pig 
GPM32320017441 | GPMDB
Resource Reanalysis 
TranscriptomicsDifferential endothelial cell gene expression by African Americans versus Caucasian Americans: A possible contribution to health disparity in vascular disease and cancer
Background: African Americans (AA) have increased burdens of cardiovascular disease and cancer compared to Caucasian Americans (CA). This study addresses the possibility that genetic differences affecting the biology of the vascular endothelium could be a factor contributing to this health disparity...
ORGANISM(S): Homo sapiens 
2010-07-02 | E-GEOD-22688 | biostudies-arrayexpress
ProteomicsRetinal proteomic profiling in the course of experimental glaucoma
Intraocular pressure was elevated through episkleral vein occlusion by thermic cauterization of SD rats. Animals were further sacrificed after different periods of elevated IOP and the retinal proteins were investigated for alterations regarding the relative protein level in this experimental model ...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081757 | MassIVE
TranscriptomicsGlobal gene expression changes in rat retinal ganglion cells after experimental glaucoma
Goals of the study: 1. Assess the gene expression profile in rat RGC after experimental IOP elevation to elucidate the molecular mechanisms of RGC death. 2. Identify potentially novel genes and pathways that may contribute to RGC death in glaucoma. Background: Glaucoma is a neurodegenerative diseas...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-12596 | biostudies-arrayexpress
TranscriptomicsRetinal vessel microarray
We sought to identify differentially expressed genes in several animal models of a retinal disease exhibiting vascular abnormalities and/or angiogenesis compared to control animals. Retinal microvessels were isolated from three models (RD1, Grhl3ct (Curlytail), VLDLR knock-out) and one rat model (R...
ORGANISM(S): Rattus norvegicus 
2013-09-13 | E-MEXP-3323 | biostudies-arrayexpress
TranscriptomicsMelphalan-treated human retinal endothelial cells
Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an organ-specific drug-delivery strategy to treat retinoblastoma, the most common primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most...
ORGANISM(S): Homo sapiens 
2011-12-13 | E-GEOD-34381 | biostudies-arrayexpress
TranscriptomicsCarboplatin-treated human retinal endothelial cells
Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an organ-specific drug-delivery strategy to treat retinoblastoma, the most common primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most...
ORGANISM(S): Homo sapiens 
2011-12-13 | E-GEOD-34379 | biostudies-arrayexpress
ProteomicsBranch retinal vein occlusion in a porcine model
Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the disease remain largely unelucidated. To bring new insights into pathological processes and elucidate potential therapeutic targets, large-scale retinal protein changes following BRVO w...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2015-07-30 | PXD001800 | Pride
Retina Brvo Pig 
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