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TranscriptomicsTranscriptome analysis of chronic lymphoid leukemia reveals isoform regulation associated with mutations in SF3B1
Several DNA sequencing studies of chronic lymphocytic leukemia (CLL) revealed that the splicing factor SF3B1 accumulated somatic point mutations in about 10 percent of the patients. In most cases the mutations were located in the genomic regions coding for the C-terminal HEAT-repeat domain and in ma...
ORGANISM(S): Homo sapiens 
2013-12-27 | E-MTAB-2025 | biostudies-arrayexpress
TranscriptomicsTranscriptional landscape, long non-coding RNAs and post-transcriptional regulation in hematopoietic stem/progenitor cell differentiation
Hematopoietic stem cells (HSC) possess life-long self-renewal activity and generate a series of multipotent progenitors that differentiate into lineage-committed progenitors and subsequently mature cells. Recently, functionally distinct stem and progenitor cell types have been identified, however, a...
ORGANISM(S): Mus musculus 
2014-10-08 | E-MTAB-1963 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome sequencing from mouse mTECs
Promiscuous gene expression (pGE) of tissue-restricted antigens in medullary thyme ephitelial cells (mTECs) is essential for self-tolerance induction and to prevent autoimmunity. We sequenced single mTEC transcriptomes to explore gene expression heterogeneity and to discover patterns of regulation o...
ORGANISM(S): Mus musculus 
2015-08-02 | E-MTAB-3346 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome sequencing from mouse mTECs (additional data)
Promiscuous gene expression (pGE) of tissue-restricted antigens in medullary thyme ephitelial cells (mTECs) is essential for self-tolerance induction and to prevent autoimmunity. We sequenced single mTEC transcriptomes to explore gene expression heterogeneity and to discover patterns of regulation o...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-MTAB-3624 | biostudies-arrayexpress
TranscriptomicsCUT&RUN of erythroblasts upon perturbation of gamma-hemoglobin repressors (part II)
Through high throughput compound screening, we've identified compounds that induce the expression of fetal hemoglobin. This study contains CUT&RUN data of a novel target, WIZ.
ORGANISM(S): Homo sapiens 
2024-06-19 | E-MTAB-13890 | biostudies-arrayexpress
UnknownUsefulness of a Mobile Application (Mentali) for Anxiety and Depression Screening in Medical Students and Description of the Associated Triggering Factors.
Not available
S-EPMC9496953 | biostudies-literature
TranscriptomicsThe Global Molecular Landscape of Hematopoietic Stem Cells and their Immediate Progeny
Hematopoietic stem cells (HSC) possess life-long self-renewal activity and generate a series of multipotent progenitors that differentiate into lineage-committed progenitors and subsequently mature cells. Recently, functionally distinct stem and progenitor cell types have been identified, however, a...
ORGANISM(S): Mus musculus 
2014-08-21 | E-MTAB-2262 | biostudies-arrayexpress
TranscriptomicsA Myc-mediated dormant state of naive ESCs
Mouse embryonic stem cells can be maintained in a naive state of pluripotency by culture conditions containing inhibitors of Mek and Gsk3. Myc activity is essential for efficient cellular reprogramming. We genetically addressed the role of c-myc and N-myc in naive ESCs cultured in 2i by inducing the...
ORGANISM(S): Mus musculus 
2016-02-11 | E-MTAB-3386 | biostudies-arrayexpress
TranscriptomicsSRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improve...
ORGANISM(S): Mus musculus 
2014-09-22 | E-GEOD-49000 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide mapping of hnRNP C and U2AF65 using iCLIP
iCLIP experiment to assess the binding of the highly abundant nuclear RNA-binding protein hnRNP C and core splicing factor U2AF65 on a genomic scale. To investigate how both proteins compete for binding at a subset of sites, U2AF65 iCLIP experiments were performed from both HNRNPC knockdown and cont...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-MTAB-1371 | biostudies-arrayexpress
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