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TranscriptomicsRNA-seq profiling of Malignant Rhabdoid Tumours
An observational experiment to methylation profile 23 SMARCB1 negative primary tumours from patients diagnosed with Malignant Rhabdoid Tumours.
ORGANISM(S): Homo sapiens 
2024-12-31 | E-MTAB-6775 | biostudies-arrayexpress
TranscriptomicsPediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study was to determi...
ORGANISM(S): Homo sapiens 
2013-01-21 | E-GEOD-35493 | biostudies-arrayexpress
TranscriptomicsGene expression data from ATRT tumor samples
Atypical teratoid/rhabdoid tumor (ATRT) is one of the most common brain tumors in infants. Although the prognosis of ATRT patients is poor, some patients respond favorably to current treatments, suggesting molecular inter-tumor heterogeneity. To investigate this further, we genetically and epigeneti...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-70678 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of Malignant Rhabdoid Tumours
An observational experiment to methylation profile 79 SMARCB1 negative primary tumours from patients diagnosed with Malignant Rhabdoid Tumours.
ORGANISM(S): Homo sapiens 
2020-07-15 | E-MTAB-6708 | biostudies-arrayexpress
ProteomicsDeep proteomic and phosphoproteomic profiling of Rhabdoid tumor response to IDA/SEL therapy
Different Rhabdoid tumors have different responses to idasanultin/selinexor therapy, which can be identified by quantitative proteomics/phospho-proteomics approach
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD049344 | Pride
Human Pediatric Selinexor Idasanutlin Rhabdoid 
TranscriptomicsDNA methylation analysis of Rhabdoid tumor of the kidney, Clear cell sarcoma of the kidney and Ewing's sarcoma family of tumors
Genome wide DNA methylation profiling of Rhabdoid tumor of the kidney, Clear cell sarcoma of the kidney, Ewing's sarcoma family of tumors and non-neoplastic kidney. The Illumina Infinium HumanMethylation 27 BeadChip was used to obtain DNA methylation profiles across approximately 27000 CpGs . Sampl...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-44847 | biostudies-arrayexpress
TranscriptomicsHigh expression of BMP pathway genes distinguishes a subset of Atypical Teratoid/Rhabdoid Tumors associated with shorter survival
Molecular profiling of tumors has proven a valuable tool for identification of prognostic and diagnostic subgroups in medulloblastomas, glioblastomas and other cancers. However, the molecular landscape of atypical teratoid / rhabdoid tumors (AT/RTs) remains largely unexplored. To address this issue,...
ORGANISM(S): Homo sapiens 
2011-09-21 | E-GEOD-28026 | biostudies-arrayexpress
TranscriptomicsExpression data of rhabdoid tumor cell line A204 treated with HDAC-inhibitor SAHA
Rhabdoid tumors are a highly aggressive pediatric tumor entity affecting infants and very young children. These tumors do not respond to conventional type chemotherapy. In recent approaches epigenetic compounds has been effective to inhibit cell growth of these tumors. Using microarray analysis we d...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-37373 | biostudies-arrayexpress
ProteomicsNatural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.
Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS-tumors of infancy and early childhood. Hallmark is the surprisingly simple genomics with a truncating mutation in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expan...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033935 | Pride
Human Primary at/rt tumors Hla-i and hla-ii 
GenomicsGenomic Sequencing of Pediatric Rhabdoid Cancers
Genomic Sequencing of Pediatric Rhabdoid Cancers
PRJNA169040 | ENA
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