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MetabolomicsDEGS1-mTORC1-driven lipid metabolic reprogramming fuels rhabdomyosarcoma progression and unveils a therapeutic vulnerability
These findings establish a mechanistic link between sphingolipid metabolism, mTORC1-mediated regulation of lipophagy, and tumor aggressiveness, highlighting lipid droplet metabolism as a novel and tractable therapeutic target in RMS.
2026-10-02 | MTBLS15896 | MetaboLights
TranscriptomicsmiRNA profiling of rhabdomyosarcoma-derived exosomes compared to donor cells, using the Affymetrix GeneChip miRNA 3.0 array
Exosomes were isolated by differential centrifugation from the fusion negative human embryonal rhabdomyosarcoma (ERMS) cell lines (JR1, Rh36, and RD) and fusion positive alveolar RMS (ARMS) cell lines (Rh30 and Rh41) and characterized by western blot for exosomal markers. miRNA content of the RMS-de...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5321 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members
Rhabdomyosarcoma (RMS) is a highly malignant tumour accounting for nearly half of soft tissue sarcomas in children. Altered miRNA levels have been reported in human cancers, including RMS. Using deep sequencing technology, a total of 685 miRNAs were investigated in a group of alveolar RMSs (ARMSs), ...
ORGANISM(S): Homo sapiens 
2015-01-28 | E-MTAB-3246 | biostudies-arrayexpress
ProteomicsPannexin 1 interactome in Rhabdomyosarcoma
We have recently reported the down-regulation of pannexin 1 (PANX1) levels in rhabdomyosarcoma (RMS) and that restoration of its expression inhibits the progression of embryonal (eRMS) and alveolar (aRMS) rhabdomyosarcoma in vitro and in vivo. While we have shown that this PANX1-mediated inhibition ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-30 | MSV000084867 | MassIVE
TranscriptomicsTranscription profiling of human Rhabdomyosarcoma biopsy samples (15 embryonal RMS, 10 translocation-positive alveolar RMS and 5 translocation-negative alveolar RMS)
We measured the expression profiles of a series of 30 Rhabdomyosarcoma biopsy samples (15 embryonal RMS, 10 translocation-positive alveolar RMS and 5 translocation-negative alveolar RMS). Expression data was used for unsupervised hierarchical clustering as well as supervised analysis to find gene ex...
ORGANISM(S): Homo sapiens 
2004-06-30 | E-MEXP-121 | biostudies-arrayexpress
TranscriptomicsHigh IGFBP2 Expression Correlates with Tumor Severity in Pediatric Rhabdomyosarcoma.
Rhabdomyosarcoma (RMS) is the most common childhood sarcoma and is identified as either the embryonal or alveolar (ARMS) subtype. In approximately 75% of cases, ARMSs are characterized by specific chromosomal translocations that involve PAX and FKHR genes. ARMS gene expression signatures vary, depen...
ORGANISM(S): Homo sapiens 
2011-12-05 | E-GEOD-23196 | biostudies-arrayexpress
ProteomicsRhabdomyosarcoma surfaceome profiling with six fusion-positive (FP) RMS cell lines, five fusion-negative (FN) RMS cell lines, and three ARMS patient-derived xenografts (PDXs)
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Prognosis for patients with high grade and metastatic disease is still very poor, and survivors are burdened with long-lasting side effects. Therefore, more effective and less toxic therapies are needed. Surface proteins are ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD039480 | Pride
Rhabdomyosarcoma Surfaceome 
TranscriptomicsEffect of genomic imbalances on gene expression in rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue sarcoma and resembles developing skeletal muscle. Specific genomic alterations including translocations, deletions and amplification events have been associated with the alveolar and embryonal subtypes of RMS. Characterizing these c...
ORGANISM(S): Homo sapiens 
2009-06-04 | E-GEOD-8840 | biostudies-arrayexpress
TranscriptomicsClinical Application of Prognostic Gene Expression Signature in Fusion Gene-Negative Rhabdomyosarcoma
To date, there are no known prognostic markers identified in patients with fusion gene-negative rhabdomyosarcoma. This study validates the 5-gene (MG5) signature as a prognostic marker in patients with fusion negative intermediate-risk rhabdomyosarcoma clearly stratifying this otherwise clinically h...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-MTAB-3580 | biostudies-arrayexpress
TranscriptomicsA mouse model of rhabdomyosarcoma originating from the adipocyte lineage
Activation of Sonic Hedgehog signaling through expression of a constitutively active Smoothened allele under control of an aP2 adipocyte-restricted transgene in mice gives rise to aggressive skeletal muscle tumors that display the histologic and molecular characteristics of human embryonal rhabdomyo...
ORGANISM(S): Mus musculus 
2012-10-22 | E-GEOD-40359 | biostudies-arrayexpress
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