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MetabolomicsTargeted metabolomic profiling of retinas from WT and Rho-Cre/Mfn1flx/flx/Mfn2flx/flx mice
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these structures include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion in each ...
2026-03-12 | MTBLS12512 | MetaboLights
TranscriptomicsTranscription profiling of mouse primary keratinocytes expressing Rho/CRIK to study the impact of Rho signaling pathway on gene expression.
Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell–cell adhesion. We report here that, surprisingly, Rho signaling suppresses dow...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3162 | biostudies-arrayexpress
TranscriptomicsRho and NusG suppress pervasive antisense transcription in Escherichia coli [RNA-seq].
Despite the prevalence of antisense transcripts in bacterial transcriptomes, little is known about how their synthesis is controlled. We report that a major function of the Escherichia coli termination factor Rho and its co-factor NusG is suppression of ubiquitous antisense transcription genome-wide...
ORGANISM(S): Escherichia coli K-12 
2012-11-01 | E-GEOD-41939 | biostudies-arrayexpress
TranscriptomicsRho directs widespread termination of intragenic and stable RNA transcription
The transcription termination factor Rho is a global regulator of RNA polymerase (RNAP). Although individual Rho-dependent terminators have been studied extensively, less is known about the sites of RNAP regulation by Rho on a genome-wide scale. Using chromatin immunoprecipitation and microarrays (...
ORGANISM(S): Escherichia coli 
2010-05-18 | E-GEOD-16562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fibroblasts to examine the cellular transformation induced by Rho subfamily GTPases
We have used microarray technology to identify the transcriptional targets of Rho subfamily GTPases. This analysis indicated that murine fibroblasts transformed by these proteins show similar transcriptomal profiles. Functional annotation of the regulated genes indicate that Rho subfamily GTPases ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5913 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of a Staphylococcus aureus mutant defective in the transcription termination factor Rho.
This analysis is part of the study Whole-transcriptome analysis of Staphylococcus aureus under laboratory and infection-mimicking conditions (Mäder, Nicolas et al., to be submitted) where the S. aureus HG001 transcriptome was analyzed under more than 40 different biological conditions. The data rev...
ORGANISM(S): Staphylococcus aureus 
2016-03-08 | E-GEOD-70041 | biostudies-arrayexpress
TranscriptomicsCharacterization of transcriptional and fitness effects of a loss of function mutation in rho
In order to study the effects of a mutation to the transcriptional termination regulator Rho (referred to as rho*), we made use of expression microarrays to observe the direct and indirect effects of rho* on gene expression. In addition, we used arrays to map the fitness of strains from transposon m...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2012-05-31 | E-GEOD-32022 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
TranscriptomicsLocalized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions
mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-IN...
ORGANISM(S): Canis lupus familiaris 
2010-05-18 | E-GEOD-13253 | biostudies-arrayexpress
TranscriptomicsE. coli MG1655Î?rac treated (N340S/G324D Rho) vs control (WT Rho)
Transcription profiling of E. coli MG1655Î?rac, comparing the effect Rho mutants (SBS: N340S, G324D) with WT Rho Organism: Escherichia coli ,Agilent Custom Escherichia coli Gene Expression Microarray 8x15K (AMADID: 020304) designed by Genotypic Technology Private Limited.
ORGANISM(S): Escherichia coli 
2016-03-28 | E-GEOD-77177 | biostudies-arrayexpress
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