Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse primary keratinocytes expressing Rho/CRIK to study the impact of Rho signaling pathway on gene expression.
Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell–cell adhesion. We report here that, surprisingly, Rho signaling suppresses dow...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3162 | biostudies-arrayexpress
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
MetabolomicsTargeted metabolomic profiling of retinas from WT and Rho-Cre/Mfn1flx/flx/Mfn2flx/flx mice
Mitochondria are dynamic organelles that undergo continuous morphological changes, yet exhibit unique, cell-type-specific structures. In rod photoreceptor cells of the retina, these structures include elongated mitochondria in the inner segments and a distinct, large, circular mitochondrion in each ...
2026-03-12 | MTBLS12512 | MetaboLights
TranscriptomicsTranscription profiling of human monocyte derived dendritic cells treated with DC-SIGN initiates an immature dendritic cell phenotype triggering Rho activation that is utilised by HIV-1
DC-SIGN is a C-type lectin expressed by dendritic cells (DCs) that binds HIV-1, sequestering it within multivesicular bodies to facilitate transmission to CD4+ T cells. Here we characterize the molecular basis of signalling through DC-SIGN by large-scale gene expression profiling and phosphoproteome...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6090 | biostudies-arrayexpress
TranscriptomicsLocalized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions
mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-IN...
ORGANISM(S): Canis lupus familiaris 
2010-05-18 | E-GEOD-13253 | biostudies-arrayexpress
UnknownQuantitative GTPase Affinity Purification Identifies Rho Family Protein Interaction Partners.
Not available
S-EPMC5217783 | biostudies-literature
TranscriptomicsSystems Modeling of the Rho Signaling Network
Describing the architecture of robust, nonlinear cell signaling networks is essential to gain a predictive understanding of cellular behavior. The structure of the Drosophila Rho-signaling network, comprised of Rho-family GTPases, RhoGTP Exchange Factors (RhoGEFs), and RhoGTPase Activating Proteins...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-18307 | biostudies-arrayexpress
TranscriptomicsConstitutively active RhoA (RhoAV14) expression and regulation of acqeous humor outflow dynamics
Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide. Regulation of aqueous humor drainage through the TM, however, is poorly understood. The role of RhoA GTPa...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-9288 | biostudies-arrayexpress
GenomicsTRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
PRJNA765042 | ENA
GenomicsYAP controls cell migration and invasion through a Rho-GTPase switch
YAP controls cell migration and invasion through a Rho-GTPase switch
PRJNA1223913 | ENA
Sort   by:  
 Page size