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Describing the architecture of robust, nonlinear cell signaling networks is essential to gain a predictive understanding of cellular behavior. The structure of the Drosophila Rho-signaling network, comprised of Rho-family GTPases, RhoGTP Exchange Factors (RhoGEFs), and RhoGTPase Activating Proteins...
ORGANISM(S): Drosophila melanogaster 
G𝛼q is a critical mediator of cell and tissue responses to stimulation of Gq-coupled receptors that regulate PLCbeta and RhoGEFs. To identify novel G𝛼q signaling partners, we performed a proximity labeling proteomic screen in HEK293A cells using TurboID-tagged GalphaQ. Top GalphaQ(Q209L) enriched ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD071839 | Pride
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