Ribosomal frameshifting

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RiboSeq of BSR cells infected at MOI 3 with Theiler's murine encephalomyelitis virus, compared to mock-infected controls, harvested at 10 hpi

BSR cells were infected with the Cardiovirus B archetype, Theiler’s murine encephalomyelitis virus (TMEV), and mutants thereof, and subjected to ribosome profiling to analyse the viral translatome, frameshifting, and ribosome pausing events. Samples were harvested at 10 hpi by flash-freezing, withou...

ORGANISM(S): Mesocricetus auratus

2021-11-10 | E-MTAB-9438 | biostudies-arrayexpress

Massively parallel reporter assay for programmed ribosomal frameshifting on designed sequence libraries

PRJNA607955 | ENA

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Programmed ribosomal frameshifting (PRF) is a fundamental gene expression event in many viruses, including SARS-CoV-2. It allows production of essential viral structural and replicative enzymes that are encoded in an alternative reading frame. Despite the importance of PRF for the viral life cycle, ...

ORGANISM(S): Homo sapiens (Human)

2021-11-25 | PXD029656 | Pride