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MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
TranscriptomicsRibosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
In higher eukaryotes, the large numbers of nuclear-encoded tRNA genes partially ensure the robustness of cytoplasmic protein translation. Here we discover that a loss-of-function in n-Tr20, a member of the nuclear-encoded tRNA Arg UCU family that is expressed specifically in the central nervous syst...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56127 | biostudies-arrayexpress
TranscriptomicsDksA Guards Elongating RNA Polymerase Against Ribosome-Stalling-Induced Arrest
In bacteria, translation-transcription coupling inhibits RNA polymerase (RNAP) stalling. We present evidence suggesting that, upon amino acid starvation, inactive ribosomes promote rather than inhibit RNAP stalling. We developed an algorithm to evaluate genome-wide polymerase progression independent...
ORGANISM(S): Escherichia coli 
2014-04-21 | E-GEOD-54669 | biostudies-arrayexpress
GenomicsRNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution
RNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution
PRJNA1003865 | ENA
UnknownThe deubiquitylase USP9X controls ribosomal stalling.
Not available
S-EPMC7849821 | biostudies-literature
GenomicsRNAP stalling-derived genome instability underlies ribosomal antibiotics efficacy and resistance evolution (ChIP-seq data)
RNAP stalling-derived genome instability underlies ribosomal antibiotics efficacy and resistance evolution (ChIP-seq data)
PRJNA1110738 | ENA
UnknownNascent MSKIK peptide cancels ribosomal stalling by arrest peptides in Escherichia coli.
Not available
S-EPMC10192921 | biostudies-literature
UnknownRibosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries.
Not available
S-EPMC6238534 | biostudies-literature
GenomicsRNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution
RNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution
PRJNA980634 | ENA
ProteomicsLC-MS/MS of co-immunoprecipitation of 3xFLAG-UFM1 from ribosomal pellet in control and upon anisomycin treatment
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (UFM1) on large ribosomal subunit protein RPL26, but the precise role of this process in ribosome-ass...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD071028 | Pride
Ufm1 Ufmylation Ribosome Anisomycin 
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