Sort   by:  
 Page size 
TranscriptomicsRibosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration
In higher eukaryotes, the large numbers of nuclear-encoded tRNA genes partially ensure the robustness of cytoplasmic protein translation. Here we discover that a loss-of-function in n-Tr20, a member of the nuclear-encoded tRNA Arg UCU family that is expressed specifically in the central nervous syst...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56127 | biostudies-arrayexpress
TranscriptomicsDksA Guards Elongating RNA Polymerase Against Ribosome-Stalling-Induced Arrest
In bacteria, translation-transcription coupling inhibits RNA polymerase (RNAP) stalling. We present evidence suggesting that, upon amino acid starvation, inactive ribosomes promote rather than inhibit RNAP stalling. We developed an algorithm to evaluate genome-wide polymerase progression independent...
ORGANISM(S): Escherichia coli 
2014-04-21 | E-GEOD-54669 | biostudies-arrayexpress
TranscriptomicsCorrecting Direct Effects of Ethanol on Translation and Transcription Machinery Confers Ethanol Tolerance in Bacteria [Ribosome_Profiling]
The molecular mechanisms of ethanol toxicity and tolerance in bacteria, while important for biotechnology and bioenergy applications, remain incompletely understood. Genetic studies have identified potential cellular targets for ethanol and revealed multiple mechanisms of tolerance, but it remains d...
ORGANISM(S): Escherichia coli 
2014-06-18 | E-GEOD-56372 | biostudies-arrayexpress
TranscriptomicsActivation of GCN2 by Ribosome Stalling Links Translation Elongation with Translation Initiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79930 | biostudies-arrayexpress
TranscriptomicsRibosome profiling study of dom34 and hbs1 knockout strains using short (16-nt) and long (28-nt) monosome-protected footprints and disome-protected footprints
Ribosomes that stall before completing peptide synthesis must be recycled and returned to the cytoplasmic pool. The protein Dom34 and cofactors Hbs1 and Rli1 can dissociate stalled ribosomes in vitro, but the identity of targets in the cell is unknown. Here we use ribosome profiling methodology to r...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-19 | E-GEOD-52968 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in cerebellum and hippocampus for mouse C57BL/6J WT and nmf205-/-
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of B6J-nmf205-/- mice in which neuronal elongation complexes are stall...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79926 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in cerebellum of mouse strains B6J, B6J-nmf205-/-, B6J-Gcn2-/- and B6J-nmf205-/-;Gcn2-/-.
Ribosome stalling during translation has recently been shown to cause neurodegeneration, yet the signaling pathways triggered by stalled elongation complexes are unknown. To investigate these pathways we analyzed the brain of B6J-nmf205-/- mice in which neuronal elongation complexes are stalled at...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-79929 | biostudies-arrayexpress
GenomicsCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
PRJNA1234593 | ENA
GenomicsCodon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
PRJNA1234592 | ENA
UnknownRole of antibiotic ligand in nascent peptide-dependent ribosome stalling.
Not available
S-EPMC3127923 | biostudies-literature
Sort   by:  
 Page size