Sort   by:  
 Page size 
ProteomicsRibosome quality control activity potentiates vaccinia virus protein synthesis during infection
Ribosomes are highly abundant cellular machines that perform the essential task of translating the genetic code into proteins. Cellular translation activity is finely tuned and proteostasis insults, such as those incurred upon viral infection, activate stress signaling pathways that result in transl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Vaccinia Virus Wr (ncbitaxon:10254) 
2021-01-05 | MSV000086660 | MassIVE
ProteomicsMapping the mammalian ribosome quality control complex interactome using proximity labeling approaches
Proximity-based (APEX and BioID) and standard affinity capture proteomics of the mammalian ribosome associated quality control complex
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-31 | MSV000082006 | MassIVE
ProteomicsZnf598-mediated Rps10/eS10 Ubiquitination contributes to the ribosome ubiquitination dynamics during zebrafish development
The ribosome is a translational apparatus that comprises about 80 ribosomal proteins and four rRNAs. Recent studies reported that ubiquitination of the ribosomal proteins plays a pivotal role in translational control and ribosome-associated quality control (RQC). However, little is known about the d...
ORGANISM(S): Danio Rerio 
PXD039560 | JPOST Repository
TranscriptomicsHistone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat
In Saccharomyces cerevisiae, ubiquitylation of histone H2B signals methylation of histone H3 at lysine residues 4 (K4) and 79. These modifications occur at active genes but are believed to stabilize silent chromatin by limiting movement of silencing proteins away from heterochromatin domains. In the...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-02 | E-GEOD-27934 | biostudies-arrayexpress
ProteomicsZNF598 substrate identification
This study uses ubiquitin proteomics to identify substrates for the ZNF598 ubiquitin ligase
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-12-08 | MSV000080390 | MassIVE
UnknownZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.
Not available
S-EPMC5321136 | biostudies-literature
TranscriptomicsCell fate determination by ubiquitin-dependent regulation of translation
Metazoan development depends on accurate execution of differentiation programs that allow pluripotent stem cells to adopt specific fates. Differentiation is brought about by global changes to chromatin architecture and transcriptional networks, yet whether other regulatory events support cell fate d...
ORGANISM(S): Homo sapiens 
2015-09-23 | E-GEOD-62247 | biostudies-arrayexpress
ProteomicsChemical damage to mRNA triggers ribosome-based quality control in the cell
Maintaining the integrity of nucleic acids is an essential feature of all organisms. Unwanted modification of DNA, if left unrepaired, is deleterious to cellular homeostasis and could have far-reaching consequences that include genomic instability and accumulation of mutations. Similarly, accumulati...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-07 | PXD013834 | Pride
Ubiquitylation Quality control Ribosome collision 
ProteomicsThe RNA-binding ubiquitin ligase MKRN1 acts as a sensor for ribosome-associated quality control of poly(A)-translation
Human cells have evolved multiple quality control mechanisms to ensure protein homeostasis by detecting aberrant mRNAs and protein products which are condemned for rapid decay. Translating ribosomes that run into poly(A) tails are terminally stalled, followed by ribosome recycling and rapid decay of...
ORGANISM(S): Homo sapiens (Human) 
2019-08-19 | PXD011772 | Pride
Ubiquitylation Rna binding Ubiquitin remnant profiling Poly(a) Mkrn1 Iclip Ribosome-associated quality control 
ProteomicsLC-MS/MS analysis of ribosome UFMylation in vitro
UFMylation, is a Ubiquitin-like modification occurring on RPL26, a ribosomal subunit, upon ribosome stalling at the ER membrane. This modification is achieved by a pool of enzymes commonly referred to as E1-activating, E2-conjugating and E3-ligase enzymes. The UFM1 E3 ligase comprises of three prote...
ORGANISM(S): Homo sapiens (Human) 
2024-03-22 | PXD046991 | Pride
In vitro reconstitution Rpl26 ufmylation Ribosome ufmylation 
Sort   by:  
 Page size