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ProteomicsER-associated degradation of Eag1 potassium channels by the RING E3 ubiquitin ligase MKRN1: the presence of a dual ubiquitination system
Mutations in the human gene encoding the neuron-specific Eag1 voltage-gated K+ channel are associated with neurodevelopmental diseases, indicating an important role of Eag1 during brain development. A disease-causing Eag1 mutant channel is linked to defective protein stability that involves enhanced...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023984 | Pride
Ring e3 Mkrn1 
ProteomicsMakorin 1 controls embryonic patterning by alleviating Bruno-mediated repression of oskar translation
Makorins are an evolutionary conserved family of proteins that contain C3H-type zinc finger modules and a RING E3 ubiquitin ligase domain. Previous analysis indicated a maternal role for Makorin 1 (Mkrn1) in Drosophila embryonic patterning and germ cell specification, but the underlying mechanism ha...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-01-29 | PXD011802 | Pride
Polyadenylation Pole plasm Germ cell specification Drosophila Oogenesis Mkrn1 
GenomicsRNA sequencing analysis of metabolism related genes in MKRN1-null mice tissues.
RNA sequencing analysis of metabolism related genes in MKRN1-null mice tissues.
PRJNA473516 | ENA
ProteomicsIntegrative Genomics Positions MKRN1 as a Novel Ribonucleoprotein within the Embryonic Stem Cell Gene Regulatory Network
For identification of proteins that associate with Makorin1 (MKRN1) in RNA-dependent and RNA-independent manners, we affinity purified FLAG-tagged Makorin1 (MKRN1) from mouse embryonic stem cells constitutively expressing FLAG:MKRN1. Anti-FLAG control immunoprecipitations were performed from a FLAG...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-21 | PXD001291 | Pride
Mkrn1 Pabpc1 Upf1 L1td1 Pabpc4 Ybx1 Igf2bp1 
ProteomicsThe RNA-binding ubiquitin ligase MKRN1 acts as a sensor for ribosome-associated quality control of poly(A)-translation
Human cells have evolved multiple quality control mechanisms to ensure protein homeostasis by detecting aberrant mRNAs and protein products which are condemned for rapid decay. Translating ribosomes that run into poly(A) tails are terminally stalled, followed by ribosome recycling and rapid decay of...
ORGANISM(S): Homo sapiens (Human) 
2019-08-19 | PXD011772 | Pride
Ubiquitylation Rna binding Ubiquitin remnant profiling Poly(a) Mkrn1 Iclip Ribosome-associated quality control 
UnknownAcceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF.
Not available
S-EPMC3490844 | biostudies-literature
TranscriptomicsIntegrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network [expression]
In embryonic stem cell (ESCs), gene regulatory networks (GRNs) coordinate gene expression to maintain ESC identity; however, the complete repertoire of factors that regulate the ESC state are not fully understood. Our previous temporal microarray analysis of ESC commitment identified the E3 Ubiquiti...
ORGANISM(S): Mus musculus 
2015-07-15 | GSE59392 | GEO
TranscriptomicsIntegrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network [RIP-chip]
In embryonic stem cell (ESCs), gene regulatory networks (GRNs) coordinate gene expression to maintain ESC identity; however, the complete repertoire of factors that regulate the ESC state are not fully understood. Our previous temporal microarray analysis of ESC commitment identified the E3 Ubiquiti...
ORGANISM(S): Mus musculus 
2015-07-15 | GSE59393 | GEO
UnknownSuppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.
Not available
S-EPMC3950322 | biostudies-literature
TranscriptomicsRNA sequencing analysis of metabolism related genes in MKRN1-null mice tissues.
Analysis of metabolism related gene expression in liver and adipose tissues from MKRN1 knockout mice.
ORGANISM(S): Mus musculus 
2018-07-01 | GSE115012 | GEO
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