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TranscriptomicsGenome wide analysis of long term L1TD1 knockdown effects in NT2D1 cell line with inducible shRNA vectors
The purpose of this study was to analyze genome wide effects of long term L1TD1 silencing in embryonal carcinoma cell line (NT2D1) and to identify molecular level mechanismis of L1TD1 function and determine its possible role in pluripotency and self-renewal Six clones from NT2D1 cell line stably exp...
ORGANISM(S): Homo sapiens 
2012-02-28 | E-GEOD-21275 | biostudies-arrayexpress
ProteomicsInteraction and global proteomics reveal the role of the pluripotency factor L1TD1 in embryonal tumor cell proliferation and mobility
Pluripotency factors are known to be abnormally expressed cancer cells, which often correlate with poor prognosis. The molecular mechanisms by which pluripotency factors contribute to tumor aggressiveness are yet to be elucidated. The pluripotency marker L1TD1 interacts with other pluripotency facto...
2024-02-09 | PXD040803 | Pride
Neuroblastoma Pluripotent Cerebellum Transcription factor Neurone Proteome Interactome L1td1 
ProteomicsPotential effect of L1TD1 on proteomics in HAP1 cells
L1TD1 is a domesticated transposon protein which a RNA-binding capacity. In this project, we aim to investigate the mechanisms through which L1TD1 acts on its RNA targets. First, we first aim to identify the de novo RNA targets of L1TD1 and then is to analyze how proteomics and transcriptomics chang...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD047402 | Pride
Hap1 cells Rna-binding protein Stability 
UnknownL1TD1 - a prognostic marker for colon cancer.
Not available
S-EPMC6651905 | biostudies-literature
GenomicsDissolution of RNA condensates by the embryonic stem cell protein L1TD1 [CLIP-seq]
Dissolution of RNA condensates by the embryonic stem cell protein L1TD1 [CLIP-seq]
PRJNA947191 | ENA
GenomicsDissolution of RNA condensates by the embryonic stem cell protein L1TD1 [RNA-seq]
Dissolution of RNA condensates by the embryonic stem cell protein L1TD1 [RNA-seq]
PRJNA947189 | ENA
UnknownDissolution of ribonucleoprotein condensates by the embryonic stem cell protein L1TD1.
Not available
S-EPMC11014241 | biostudies-literature
OtherIdentification of L1TD1-associated transcripts in DNMT1 KO HAP1 cells
In this study, we aimed at determining RNA interactors of L1TD1 RNPs. To achieve this, DNMT1 KO and DNMT1 L1TD1 DKO HAP1 cells were generated by Crispr/Cas9 gene editing tool and L1TD1 RIP was performed by using these cell lines. Our study reveals a comprehensive analysis of differentially enriched ...
ORGANISM(S): Homo sapiens 
2025-01-01 | GSE254459 | GEO
OtherDissolution of RNA condensates by the embryonic stem cell protein L1TD1 [CLIP-seq]
L1TD1 is a cytoplasmic RNA-binding protein that is specifically expressed in pluripotent stem cells and, unlike its mouse paralogue, is essential for the maintenance of stemness in human cells. Although L1TD1 is the only known domesticated gene from a LINE-1 (L1) retroelement, the functional legacy ...
ORGANISM(S): Homo sapiens 
2023-04-26 | GSE227855 | GEO
TranscriptomicsDissolution of RNA condensates by the embryonic stem cell protein L1TD1 [RNA-seq]
L1TD1 is a cytoplasmic RNA-binding protein that is specifically expressed in pluripotent stem cells and, unlike its mouse paralogue, is essential for the maintenance of stemness in human cells. Although L1TD1 is the only known domesticated gene from a LINE-1 (L1) retroelement, the functional legacy ...
ORGANISM(S): Homo sapiens 
2023-04-26 | GSE227854 | GEO
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