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TranscriptomicsTranscription profiling of Arabidopsis acn1-2 and Col-7 lines to investigate the links between organic acid and carbohydrate regulation of gene expression.
Arabidopsis acetate non-utilizing mutants were isolated based on fluoroacetate resistant germination. Interestingly, a number of these mutants exhibited altered developmental characteristics in response to exogenous sucrose supply, such as bleaching of the cotyledons. A preliminary microarray exper...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6158 | biostudies-arrayexpress
GenomicsA SNF2 protein targets variable copy number repeats and thereby influences allele-specific expression
ATRX is an X-linked gene of the SWI/SNF family whose role in vivo is currently unknown. Mutations in ATRX cause syndromal mental retardation. ATRX binds to tandem repeat (TR) sequences both in heterochromatin (e.g. telomeres) and euchromatin. Genes associated with these TRs can be dysregulated when ...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-22162 | biostudies-arrayexpress
ProteomicsParacrine secretion of monounsaturated fatty acids prevents ferroptosis in triple negative breast cancer and reveals selenocysteine synthesis dependency for metastatic seeding.
The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a cell death caused by iron-dependent lipid peroxidation counteracted by the antioxidant activity of selenop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-17 | MSV000094784 | MassIVE
TranscriptomicsTranscription profiling of rat arteries from animals with salt induced hypertensive disease results in over expression of matricellular genes in cerebral arteries
The Dahl salt-sensitive (S) rat model develops chronic hypertensive disease when fed a high salt diet that ultimately results in renal and heart failure, as well as prevalent cerebrovascular pathologies. Phenotypic changes in the cerebral vasculature are preceded by changes in gene expression, and ...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5488 | biostudies-arrayexpress
UnknownExpression Changes of Structural Protein Genes May Be Related to Adaptive Skin Characteristics Specific to Humans.
Not available
S-EPMC6402313 | biostudies-literature
UnknownIntegrative Multiomic Profiling of Triple-Negative Breast Cancer for Identifying Suitable Therapies.
Not available
S-EPMC11474168 | biostudies-literature
UnknownAn integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia.
Not available
S-EPMC7560828 | biostudies-literature
GenomicsThe BTB-zinc finger transcription factor Abrupt acts as an epithelial oncogene in Drosophila through maintaining a progenitor-like cell state
The capacity of tumor cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila we carried out an overexpression screen for oncogenes capable of cooperating with the loss of the epithelial api...
ORGANISM(S): Drosophila melanogaster 
2013-08-15 | E-GEOD-42928 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast timecourse mcs6 mutant
The fission yeast Mcs6-Mcs2-Pmh1 complex (homologous to metazoan Cdk7-cyclin HMat1) performs dual functions: in cell cycle control, as a CDK-activating kinase; and in transcription by RNA polymerase (Pol) II, as part of TFIIH. It is unknown whether that linkage serves to coordinate gene expression w...
ORGANISM(S): Schizosaccharomyces pombe 
2004-11-01 | E-MEXP-192 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of fission yeast timecourse pmh1 mutant
The fission yeast Mcs6-Mcs2-Pmh1 complex (homologous to metazoan Cdk7-cyclin HMat1) performs dual functions: in cell cycle control, as a CDK-activating kinase; and in transcription by RNA polymerase (Pol) II, as part of TFIIH. It is unknown whether that linkage serves to coordinate gene expression w...
ORGANISM(S): Schizosaccharomyces pombe 
2004-11-01 | E-MEXP-191 | biostudies-arrayexpress
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