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UnknownLongitudinal associations between diurnal cortisol variation and later-life cognitive impairment.
Not available
S-EPMC6988984 | biostudies-literature
UnknownStudy protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury.
Not available
S-EPMC10083765 | biostudies-literature
UnknownPS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.
Not available
S-EPMC6740398 | biostudies-literature
TranscriptomicsPeripheral Blood Mononuclear Cell Gene Expression Profiles May Predict Poor Outcome in Idiopathic Pulmonary Fibrosis [Affymetrix]
Background: In this study we aimed to identify peripheral blood mononuclear cell (PBMC) gene expression profiles predictive of poor outcomes in idiopathic pulmonary fibrosis (IPF) Methods: Microarray analyses of PBMC were performed in 120 patients from discovery (n=45) and replication cohorts (n=7...
ORGANISM(S): Homo sapiens 
2013-10-15 | E-GEOD-27957 | biostudies-arrayexpress
ProteomicsReduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion
Autophagy is essential for protein quality control and regulation of the functional proteome. Failure of autophagy pathways with age contributes to loss of proteostasis in aged organisms and accelerates progression of age-related diseases. In this work, we show that activity of endosomal microautoph...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035128 | Pride
Autophagy Chaperones Aging Proteostasis Lc-ms/ms 
UnknownHaemodynamic changes in visceral hybrid repairs of type III and type V thoracoabdominal aortic aneurysms.
Not available
S-EPMC10447573 | biostudies-literature
TranscriptomicsPeripheral Blood Mononuclear Cell Gene Expression Profiles May Predict Poor Outcome in Idiopathic Pulmonary Fibrosis
Background: In this study we aimed to identify peripheral blood mononuclear cell (PBMC) gene expression profiles predictive of poor outcomes in idiopathic pulmonary fibrosis (IPF) Methods: Microarray analyses of PBMC were performed in 120 patients from discovery (n=45) and replication cohorts (n=7...
ORGANISM(S): Homo sapiens 
2013-10-15 | E-GEOD-28221 | biostudies-arrayexpress
TranscriptomicsGene expression and genotype in normal heart
Genome-wide association studies have identified a small region at chromosome 9p21.3 strongly associated with coronary heart disease risk. The region contains no protein-coding genes and the mechanism underlying its association with heart disease is unknown. We investigated associations between rs133...
ORGANISM(S): Homo sapiens 
2012-07-03 | E-GEOD-22253 | biostudies-arrayexpress
UnknownVariability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial Resistance Network individual patient data meta-analysis.
Not available
S-EPMC10243075 | biostudies-literature
MetabolomicsPrediction of complex phenotypes using the Drosophila melanogaster metabolome
Understanding the genotype-phenotype map and how variation at different levels of biological organization is associated are central topics in modern biology. Fast developments in sequencing technologies and other molecular omic tools enable researchers to obtain detailed information on variation at ...
2021-08-05 | MTBLS2060 | MetaboLights
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