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MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
TranscriptomicsThe Genomics of the Fetal Hypothalamic Cellular Response to Transient Hypoxia: Endocrine, Immune, and Metabolic Responses
Fetuses respond to transient hypoxia (a common stressor in utero) with cellular responses that are appropriate for promoting survival of the fetus. The present experiment was performed to identify the acute genomic responses of the fetal hypothalamus to transient hypoxia. Three fetal sheep were ex...
ORGANISM(S): Ovis aries 
2014-01-16 | E-GEOD-43371 | biostudies-arrayexpress
TranscriptomicsTranscriptomics Responses to Hypoxia and Ketamine in Ovine Fetal Cerebral Cortex
Transient hypoxia in pregnancy stimulates a physiological reflex response that redistributes blood flow and defends oxygen delivery to the fetal brain. The chemoreceptor reflex that is responsible for this physiological response is dependent on glutamatergic neurotransmission which, in times of vig...
ORGANISM(S): Ovis aries 
2016-04-06 | E-GEOD-76110 | biostudies-arrayexpress
TranscriptomicsKetamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex
Acute fetal hypoxia is a form of fetal stress that stimulates renal vasoconstriction and ischemia as a consequence of the physiological redistribution of combined ventricular output. We have demonstrated that hypoxia in late ovine gestation induces inflammation in the brain that is ameliorated by tr...
ORGANISM(S): Ovis aries 
2016-09-01 | E-GEOD-66920 | biostudies-arrayexpress
GenomicsDAC for Dave Lab, Duke University
Data Access Committee EGAC00001000538
EGAC00001000538 | EGA
GenomicsGenetic and Functional Drivers of Diffuse Large B Cell Lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common hematologic malignancy and is characterized by a striking degree of heterogeneity. We enrolled a total of 1001 DLBCL patients and comprehensively defined the landscape of genetic mutations, copy number alterations and expression through whole-...
EGAS00001002606 | EGA
Genomicsena-DATASET-DAVELAB-01-09-2017-13:58:58:766-116 - samples
Exome sequencing data for 1001 DLBCL patients and RNA sequencing data for 775 DLBCL patients
EGAD00001003600 | EGA
UnknownUpdate on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited.
Not available
S-EPMC3286387 | biostudies-literature
UnknownThe benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.
Not available
S-EPMC3386495 | biostudies-literature
UnknownEffect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke.
Not available
S-EPMC4731690 | biostudies-literature
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