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TranscriptomicsIdentification of nine genomic regions of amplification in bladder cancer, correlation with stage, and potential prognositic and therapeutic value
We sought to test the hypothesis that ascertainment of genome-wide copy number alterations in bladder cancer may have value for clinical management. We performed a genome wide analysis of 164 bladder cancer samples and 27 bladder cancer cell lines to identify genetic changes associated with disease ...
ORGANISM(S): Homo sapiens 
2013-04-29 | E-GEOD-44323 | biostudies-arrayexpress
TranscriptomicsCombination of a novel gene expression signature with a clinical nomogram improves the prediction of survival in high-risk bladder cancer Â
Urothelial carcinoma of the bladder is characterized by significant variability in clinical outcomes depending on stage and grade. The addition of molecular information may improve our understanding of such heterogeneity and enhance prognostic prediction. The purpose of this study was to validate an...
ORGANISM(S): Homo sapiens 
2012-01-23 | E-GEOD-31684 | biostudies-arrayexpress
TranscriptomicsDNA copy number gain at 1q23.3 is associated with poor survival in metastatic bladder cancer [Agilent]
Metastatic urothelial carcinoma (UC) of the bladder is associated with multiple somatic copy number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic UC treated with platinum chemotherapy. We obtained overall survival (OS) and DNA copy number...
ORGANISM(S): Homo sapiens 
2013-07-07 | E-GEOD-39281 | biostudies-arrayexpress
TranscriptomicsDNA copy number gain at 1q23.3 is associated with poor survival in metastatic bladder cancer [Affymetrix]
Metastatic urothelial carcinoma (UC) of the bladder is associated with multiple somatic copy number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic UC treated with platinum chemotherapy. We obtained overall survival (OS) and DNA copy number...
ORGANISM(S): Homo sapiens 
2013-07-07 | E-GEOD-39280 | biostudies-arrayexpress
TranscriptomicsDNA copy number gain at 1q23.3 is associated with poor survival in metastatic bladder cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-07-07 | E-GEOD-39282 | biostudies-arrayexpress
TranscriptomicsHuman non-GCIMP gioblastoma subtypes evolve from a common proneural-like precursor glioma
In order to understand the relationships between the human non-GCIMP glioblastoma subgroups, we performed computational analysis of human genomic data to predict the temporal sequence in which the driver events arise during tumorigenesis. The order of evolutionary events for non-GCIMP GBM is 1) chr ...
ORGANISM(S): Mus musculus 
2014-04-03 | E-GEOD-45874 | biostudies-arrayexpress
TranscriptomicsRecruitment of MYC to target genes in ramos and mutu3 cells
Follicular lymphomas and diffuse large B-cell lymphomas have markedly different biological phenotypes and yet all originate from mature, germinal center B-cells. We hypothesized that alterations in DNA methylation patterning might help explain the clinical heterogeneity of these diseases. We report ...
ORGANISM(S): Homo sapiens 
2012-11-27 | E-GEOD-31110 | biostudies-arrayexpress
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