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TranscriptomicsDual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer
Using a retrovirus-mediated cDNA expression cloning approach we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and t...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43610 | biostudies-arrayexpress
TranscriptomicsHigh-resolution analysis of copy number changes in circulating and disseminated tumor cells in breast cancer patients
The aim of this study was to establish a single-cell array comparative genomic hybridization (SCaCGH) method providing in-depth genomic analysis of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs). The robustness and resolution limits of the method were estimated with different cel...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-27574 | biostudies-arrayexpress
Genomicsena-DATASET-MUG-10-03-2014-08:56:10:089-189 - samples
In order to establish copy number profiles from the various samples we prepared libraries and subjected them to whole-genome sequencing at a shallow sequencing depth (0.1x)
EGAD00001000761 | EGA
Genomicsena-DATASET-MUG-10-03-2014-08:59:23:443-190 - samples
We utilized exome sequencing for DNA obtained from saliva (germline DNA) and the four spatially separated tumor foci and 3 corresponding lymph node metastases
EGAD00001000762 | EGA
Genomicsena-DATASET-MUG-10-03-2014-09:03:11:084-191 - samples
We used targeted deep sequencing to accurately establish the allele frequencies of the mutations identified by exome sequencing
EGAD00001000763 | EGA
GenomicsDivergence between high metastatic tumor burden and low circulating tumor DNA concentration in metastasized breast cancer
Circulating tumor DNA (ctDNA) was reported to represent a highly sensitive biomarker of metastatic cancer disease directly reflecting tumor burden and dynamics. Here we investigated the role of ctDNA in patients with metastatic breast cancer. In an index patient with more than 100,000 circulating tu...
EGAS00001000625 | EGA
Genomicsena-DATASET-MUG-17-05-2013-08:29:19:239-74 - samples
We performed serial plasma-Seq analyses on a male who progressed from castration-sensitive to castration-resistant prostate cancer within 10 months following treatment with androgen-deprivation therapy.
EGAD00001000396 | EGA
Genomicsena-DATASET-MUG-19-03-2013-14:10:31:964-87 - samples
We performed low coverage whole genome sequencing of plasma DNA from prostate cancer patients to establish copy number profiles on both a genome-wide and a gene-specific level. The data include plasma samples from prostate cacner patients (n=13), non-malignant controls (males, n=10 and females, n=9)...
EGAD00001000364 | EGA
Genomicsena-DATASET-MUG-19-03-2013-14:14:47:994-92 - samples
In this study we analysed patients with metastatic prostate cancer to scan their tumor genomes noninvasively in plasma DNA. We enriched 1.3 Mbp of seven plasma DNAs (4 CRPC cases: CRPC1-3 and CRPC5; 3 CSPC cases: CSPC1-2 and CSPC4) including exonic sequences of 55 cancer genes and 38 introns of 18 g...
EGAD00001000365 | EGA
GenomicsPlasma-Seq of patients with metastatic prostate cancer
Study 1 In this study we analysed patients with metastatic prostate cancer to scan their tumor genomes noninvasively in plasma DNA. We wanted to make whole-genome analysis from plasma DNA amenable to clinical routine applications and developed an approach based on a benchtop high-throughput platform...
EGAS00001000451 | EGA
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