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TranscriptomicsIdentification of avian RIG-I responsive genes during influenza infection
Transcriptional profiling of chicken embryonic fibroblasts (DF-1 cells) comparing the effects of chicken cells transfected with duck RIG-I compared to empty-vector transfected cells following with low or highly pathogenic avian influenza. Goal was to determine the effects of duck RIG-I on influenza-...
ORGANISM(S): Gallus gallus 
2012-12-12 | E-GEOD-29596 | biostudies-arrayexpress
TranscriptomicsSystems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity [comparison]
The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short hairpin dsRNA and 5M-bM-^@M-^Y triphosphate (5M-bM-^@M-^Yppp) terminal structure. In the present study, an RNA agonist of RIG-I was synthesized ...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-60572 | biostudies-arrayexpress
TranscriptomicsSystems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity [Kinetic]
The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short hairpin dsRNA and 5M-bM-^@M-^Y triphosphate (5M-bM-^@M-^Yppp) terminal structure. In the present study, an RNA agonist of RIG-I was synthesized ...
ORGANISM(S): Homo sapiens 
2014-08-21 | E-GEOD-60573 | biostudies-arrayexpress
TranscriptomicsGene expression in IRF3-/- peritoneal macrophage infected with VSV
IRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and RIG-I-like receptor) signalling pathway. IRF3 is known to induce the expression of type I IFN gene upon virus infection. To furter examine the role of IRF3 in virus-i...
ORGANISM(S): Mus musculus 
2012-05-19 | E-GEOD-37855 | biostudies-arrayexpress
GenomicsKnockdown IGF-1R triggers viral RNA sensors MDA5- and RIG-1-mediated the mitochondrial apoptosis in colonic cancer cells
Knockdown IGF-1R triggers viral RNA sensors MDA5- and RIG-1-mediated the mitochondrial apoptosis in colonic cancer cells
PRJNA505500 | ENA
TranscriptomicsKnockdown IGF-1R triggers viral RNA sensors MDA5- and RIG-1-mediated the mitochondrial apoptosis in colonic cancer cells
The important role of IGF-1R in cancers has been well established. Classical model involves IGF-1/2 binding to IGF-1R, following activation of the PI3K/Akt pathway, thereby promoting cell proliferation, apoptosis inhibition and treatment resistance. While IGF-1R has become a promising target for can...
ORGANISM(S): Homo sapiens 
2019-11-30 | GSE122534 | GEO
UnknownGasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway.
Not available
S-EPMC10767184 | biostudies-literature
UnknownLatent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway.
Not available
S-EPMC6031712 | biostudies-literature
GenomicsY RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1
Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1
PRJNA838613 | ENA
UnknownSimultaneous Detection of RIG-1, MDA5, and IFIT-1 Expression Is a Convenient Tool for Evaluation of the Interferon-Mediated Response.
Not available
S-EPMC9609481 | biostudies-literature
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