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ProteomicsOTS Development and E. coli Proteome LC-MSMS
Over the past twenty years, the development of orthogonal biological systems has sparked a revolution in our ability to study cellular physiology. Orthogonal translation systems (OTSs) enable site-specific incorporation of hundreds of non-standard amino acids, offering unprecedented access to the st...
ORGANISM(S): Escherichia coli 
2023-07-27 | PXD026217 | Pride
Lc-msms Ots Proteome Ms reporter 
ProteomicsOrganisms with alternative genetic codes resolve unassigned codons via mistranslation and ribosomal rescue
Organisms possessing genetic codes with unassigned codons raise the question of how cellular machinery resolves such codons and how this could impact horizontal gene transfer. Here, we use a genomically recoded Escherichia coli to examine how organisms address translation at unassigned UAG codons, w...
ORGANISM(S): Escherichia coli 
2018-09-18 | PXD009643 | Pride
E coli Lc-ms/ms 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Escherichia coli 
2022-11-11 | PXD026422 | Pride
Synthetic biology Proteomics Phosphoproteome Phosphoprotein interactions Checkpoint kinase 2 14-3-3 Kinase Orthogonal translation system Genetic code expansion phosphothreonine 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Escherichia coli 
2022-11-11 | PXD026423 | Pride
Synthetic biology Proteomics Phosphoproteome Phosphoprotein interactions Checkpoint kinase 2 14-3-3 Kinase Orthogonal translation system Genetic code expansion phosphothreonine 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Escherichia coli 
2022-11-11 | PXD026421 | Pride
Synthetic biology Proteomics Phosphoproteome Phosphoprotein interactions Checkpoint kinase 2 14-3-3 Kinase Orthogonal translation system Genetic code expansion phosphothreonine 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-11 | PXD026420 | Pride
Orthogonal translation system Phosphoproteome Phosphothreonine Checkpoint kinase 2 Genetic code expansion 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Escherichia coli 
2022-11-11 | PXD026425 | Pride
Synthetic biology Proteomics Phosphoproteome Phosphoprotein interactions Checkpoint kinase 2 14-3-3 Kinase Orthogonal translation system Genetic code expansion phosphothreonine 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-11 | PXD026432 | Pride
Synthetic biology Proteomics Phosphoproteome Phosphoprotein interactions Checkpoint kinase 2 14-3-3 Kinase Orthogonal translation system Genetic code expansion phosphothreonine 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-11 | PXD026426 | Pride
Synthetic biology Proteomics Phosphoproteome Phosphoprotein interactions Checkpoint kinase 2 14-3-3 Kinase Orthogonal translation system Genetic code expansion phosphothreonine 
ProteomicsEnhanced Access to the Human Phosphoproteome with Genetically Encoded Phosphothreonine
Protein phosphorylation is a ubiquitous post-translational modification that governs signaling cascades and protein-protein interactions. Orthogonal translation systems repurpose evolutionarily divergent aminoacyl-tRNA synthetase and tRNA pairs for the co-translational insertion of a modified amino ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-11 | PXD026427 | Pride
Synthetic biology Proteomics Phosphoproteome Phosphoprotein interactions Checkpoint kinase 2 14-3-3 Kinase Orthogonal translation system Genetic code expansion phosphothreonine 
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