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MetabolomicsEC and PVC from 14-15 month-old APOE3/3, APOE3/4 and APOE4/4 mice
Not available
ORGANISM(S): Mus musculus 
ST001819 | MetabolomicsWorkbench
ProteomicsPolypharmacological perturbation of the 14-3-3 adaptor protein interactome stimulates neurite outgrowth
Targeting protein-protein interactions (PPIs) is a promising, but under-exploited, approach in the development of drugs for many indications. 14-3-3 proteins are a family of adaptor molecules with ubiquitous and critical functions in dozens of cell signaling networks. 14-3-3s bind to hundreds of ‘cl...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-03-31 | PXD017317 | Pride
Regeneration Axon 14-3-3 Rap1 Polypharmacology 
GenomicsUndibacterium sp. 14-3-2
Undibacterium sp. 14-3-2 Genome sequencing and assembly
PRJNA688602 | ENA
ProteomicsPIM1 phosphorylation of 14-3-3 ζ in vitro
We previously identified 14-3-3 ζ S64 as a substrate of PIM1 in an in vivo chemical genetic screen. To verify this phosphorylation event and determine whether S64 is the predominant phosphorylation site, we performed in vitro phosphorylation of 14-3-3 ζ by PIM1.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2021-11-25 | PXD023623 | Pride
Pim1 Protein phosphorylation Kinase 14-3-3 ζ 
ProteomicsTargeted Protein Localization by Covalent 14-3-3 Recruitment
chemoproteomic profiling of covalent ligands that target 14-3-3
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-08-28 | PXD054696 | Pride
14-3-3 
ProteomicsStructural basis of the cyclin Y/14-3-3 protein-mediated activation of CDK16
Cyclin-dependent protein kinase 16 (CDK16) regulates both physiological and pathological processes, including autophagy, spermatogenesis and cancer. Unlike other CDKs, CDK16 is regulated by an unclear mechanism involving phosphorylated cyclin Y (CCNY) in complex with 14-3-3 proteins rather than CCNY...
ORGANISM(S): Escherichia coli 
2026-03-31 | PXD074528 | Pride
Structure Cdk16 Cyclin y/14-3-3 
ProteomicsThe subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3
The subcortical maternal complex (SCMC) is essential for the maintenance of female fertility in mammals. Most pathogenic mutations in SCMC-encoding genes result in female reproductive failure characterized by early embryonic arrest. Assembled in oocytes, the SCMC maintains the normal cleavage of ear...
ORGANISM(S): Mus Musculus Spodoptera Frugiperda 
PXD055498 |
ProteomicsLight-triggered and phosphorylation-dependent 14-3-3 association with NON-PHOTOTROPIC HYPOCOTYL 3 is required for hypocotyl phototropism
NON-PHOTOTROPIC HYPOCOTYL 3 (NPH3) is a key component of the auxin-dependent plant phototropic growth response. We report that NPH3 directly binds polyacidic phospholipids, required for plasma membrane association in darkness. We further demonstrate that blue light induces an immediate phosphorylati...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-10-12 | PXD028530 | Pride
Arabidopsis thaliana Etiolated seedling Blue-light dependent 14-3-3 interactors 
Proteomics14-3-3 affinity capture to identify new targets of 14-3-3 signaling during dsRNA-stimulation in human keratinocytes.
We have combined two proteomic approaches, phosphoproteomics and 14-3-3 affinity capture, to examine the signaling pathways in which 14-3-3 proteins participate and to identify new targets of 14-3-3 signaling during dsRNA-stimulation.
ORGANISM(S): Homo sapiens (Human) 
2014-08-05 | PXD000677 | Pride
Human Itraq Hacat keratinocytes Lc-ms/ms 
Proteomics14-3-3θ Phosphorylation at S232 Reduces its Interactome and Regulates Axonal Trafficking
14-3-3 proteins impact protein-protein interactions (PPIs) that regulate neuronal functions. The 14-3-3θ isoform is protective in Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) models. Human PD and DLB brains show increased 14-3-3θ phosphorylation at S232. To understand the impact of 1...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-25 | PXD071112 | Pride
Axonal trafficking Affinity-purification mass spectrometry 14-3-3θ Parkinson’s disease Dementia with lewy bodies 
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