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ProteomicsAntibody RING-Mediated Destruction (ARMeD) of endogenous proteins
To help understand the cellular function of a gene the encoding DNA or mRNA transcript can be manipulated and the consequences observed. However, these approaches do not have a direct effect on the protein product of the gene, which is either permanently abrogated or depleted at a rate defined by th...
ORGANISM(S): Homo Sapiens 
2020-05-28 | PXD016193 | panorama
ProteomicsAntibody RING-Mediated Destruction (ARMeD) of endogenous proteins
To understand the cellular function of a gene the encoding DNA or mRNA transcript can be manipulated and the consequences observed. However, these approaches do not have a direct effect on the protein product of the gene, which is either permanently abrogated or depleted at a rate defined by the hal...
ORGANISM(S): Homo sapiens (Human) 
2020-05-29 | PXD018113 | Pride
Ring ubiquitin nanobody endogenous degradation 
UnknownTargeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression.
Not available
S-EPMC12549912 | biostudies-literature
ProteomicsLC-MS data of IM95 gastric cancer cells following YAP degradation by bioPROTAC
In this study, through naïve nanobody phage library screening, we have identified multiple nanobodies against human YAP with high affinity and specificity. The YAP nanobody was then fused to the RING domain of RNF4, creating a bio-Proteolysis-Targeting Chimera (bioPROTAC) molecule capable of selecti...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD063726 | Pride
Gastric cancer cells Yap Bioprotac 
UnknownAntibody RING-Mediated Destruction of Endogenous Proteins.
Not available
S-EPMC7332993 | biostudies-literature
UnknownQuantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-β Signaling Pathway.
Not available
S-EPMC8665411 | biostudies-literature
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