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ProteomicsPRMT1-mediated methylation of the Large Drosha Complex regulates microRNA biogenesis
MicroRNA (miRNA) biogenesis is a tightly controlled multi-step process operated in the nucleus by the activity of the Large Drosha Complex (LDC). Through high resolution mass spectrometry (MS) analysis we discovered that the LDC is extensively methylated, with 82 distinct methylated sites associated...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD011617 | Pride
Prmt1 Large drosha complex Mass spectrometry Microrna Protein methylation 
TranscriptomicsRNA-seq of the brain of Nothobranchius furzeri at different time points
Background: Comparison of temporal gene expression profiles (www.jenage.de) The RNA-seq data comprises 5 age groups: 5,12,20,27,39 weeks 25 samples: 5 biological replicates for each age group
ORGANISM(S): Nothobranchius furzeri 
2014-07-29 | E-GEOD-52462 | biostudies-arrayexpress
ProteomicsRNA-host protein interaction analyses reveal additional proteins involved in SARS-CoV-2 RNA biology
SARS-CoV-2 is a positive single-stranded RNA virus which interacts at different stages with the host proteins of infected cells. These interactions are necessary for the host to recognize and block the replication of the virus. But, at the same time, the virus requires host proteins to translate, tr...
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD034941 | Pride
Ars-cov-2  interactome  host-virus interactions  rbps 
ProteomicsTFIIIC dinamically binds Alu elements to control gene expression through chromatin looping
Folding of the mammalian genome is governed by architectural proteins, such asCTCF. TFIIIC, a RNA polymerase III transcription factor, has been identified as aninsulator but its role in genome topology is totally unknown. Here, we show that TFIIICestablishes long-range genomic interactions that affe...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD011250 | Pride
Human Breast cancer Alu Tfiiic 
UnknownMitochondrial translocation of TFEB regulates complex I and inflammation
Not available
S-SCDT-10_1038-S44319-024-00058-0 | biostudies-other
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