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TranscriptomicsTranscription profiling of human xenografted nasopharyngeal carcinoma tumor cell lines and an untransformed diploid fibroblast cell line
The aim of this experiment was to investigate the gene expression profile of two xenografted nasopharyngeal carcinoma tumors - C15 and C17 – which are international reference tools for biological investigations of this type of disease. C15 and C17 transcriptome was profiled by comparison with human...
ORGANISM(S): Homo sapiens 
2007-12-01 | E-TABM-382 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human nevoid basal cell carcinoma syndrome primary fibroblasts with non-sense or miss-sense mutations in the tumor supressor gene PTCH1
Mutations in the tumor suppressor gene PTCH1 are responsible for Gorlin syndrome, or nevoid basal cell carcinoma syndrome (NBCCS). NBCCS causes predisposition to basal cell carcinoma (BCC), the commonest cancer in adult human. In the general population BCC develop almost exclusively in sun-exposed a...
ORGANISM(S): Homo sapiens 
2009-03-19 | E-TABM-549 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+ leukemia Jurkat T-cells in which the PI3K pathway is constitutively turned-on and FOXO1 transcriptional activity strongly repressed
One major effect of PI3-kinase activation downstream of the serine/threonine kinase Akt is the phosphorylation of the transcription factor FOXO1 and its neutralization. FOXO1 has several ubiquitous targets genes in many cell types that control cell quiescence, oxydative stress or apoptosis. However,...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-TABM-391 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of non-small cell lung carcinoma cell line H1975 treated with cisplatin or BMS-69014 a novel panHER/VEGFR inhibitor
Non-small cell lung cancer (NSCLC) with activating mutations in the epidermal growth factor receptor (EGFR) responds to EGFR tyrosine kinase inhibitors such as erlotinib. However, secondary somatic EGFR mutations (e.g. T790M) confer resistance to erlotinib. BMS-690514, a novel panHER/VEGFR inhibitor...
ORGANISM(S): Homo sapiens 
2007-07-24 | E-TABM-239 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of MYCN non-amplified stage 4S neuroblastomas
Molecular phenotype of MYCN non-amplified stage 4S neuroblastoma
ORGANISM(S): Homo sapiens 
2009-05-05 | E-TABM-119 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses
The profiles of transcripts of Mo7e cells transduced with control- or p210(BCR-ABL)-GFP viruses were compared using microarrays to investigate
ORGANISM(S): Homo sapiens 
2007-10-31 | E-TABM-173 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of GR-N-91 neuroblasts injected subcutaneously into nude mice and a primary tumor Xenograft (PTX) was isolated whilst metastatic neuroblasts were isolated from Myocardium (MY) and Bone Marrow (BM)
We have used an IGR-N-91 parental cell line established from an involved bone marrow harvested from a high-risk NB (stage 4-NB, 8 year-old boy). These IGR-N-91 neuroblasts were injected subcutaneously into nude mice and a Primary Tumor Xenograft (PTX) was isolated whilst metastatic neuroblasts were...
ORGANISM(S): Homo sapiens 
2006-09-11 | E-TABM-44 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ cells from familial platelet disorder
Characterize the genes deregulated in CD34 positive cells from peripheral blood of FPD/AML patients harbouring two different RUNX1 mutations. RUNX1 (also called AML1), a DNA-binding subunit of the CBF transcription factor family, is a master regulatory gene in hematopoiesis and acts as a tumour supp...
ORGANISM(S): Homo sapiens 
2010-09-11 | E-TABM-792 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human tumor cell line TPC-1 treated with siRNAs targetting RET mRNA and the RET/PTC1 junction
Genomic rearrangements leading to intragenic gene fusion are mainly found in some types of haematopoietic malignancies and sarcomas. Recently they have been described also in carcinomas such as the papillary thyroid histotype (60%-70%) and the Hürthle thyroid tumours (58%). The presence of junction ...
ORGANISM(S): Homo sapiens 
2010-05-01 | E-TABM-746 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 23 human thyroid tissues including 11 normal tissue, 4 follicular thyroid adenomas and 8 follicular thyroid carcinomas, in order to identify molecular profile associated with PAX8PPARgamma translocation
Study of a series of 23 human thyroid tissues including 11 normal tissue, 4 follicular thyroid adenomas and 8 follicular thyroid carcinomas, in order to identify molecular profile associated with PAX8PPARgamma translocation. The main factor is presence of PAX8PPARgamma translocation. Other clinical ...
ORGANISM(S): Homo sapiens 
2005-06-28 | E-TABM-11 | biostudies-arrayexpress
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