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TranscriptomicsCOMPARATIVE SYSTEMS TOXICOLOGY ANALYSIS OF CIGARETTE SMOKE AND AEROSOL FROM A CANDIDATE MODIFIED RISK TOBACCO PRODUCT IN ORGANOTYPIC HUMAN GINGIVAL EPITHELIAL CULTURES: A 3-DAY REPEATED EXPOSURE STUDY.
Smoking is one of the major lifestyle-related risk factors for periodontal diseases. Modified risk tobacco products (MRTP) offer a promising alternative in the harm reduction strategy for adult smokers unable to quit. Using a systems toxicology approach, we investigated and compared the exposure eff...
ORGANISM(S): Homo sapiens 
2017-04-01 | E-MTAB-5609 | biostudies-arrayexpress
TranscriptomicsCOMPARATIVE SYSTEMS TOXICOLOGY ANALYSIS OF CIGARETTE SMOKE AND AEROSOL FROM A CANDIDATE MODIFIED RISK TOBACCO PRODUCT IN ORGANOTYPIC HUMAN GINGIVAL EPITHELIAL CULTURES: A 3-DAY REPEATED EXPOSURE STUDY.
Smoking is one of the major lifestyle-related risk factors for periodontal diseases. Modified risk tobacco products (MRTP) offer a promising alternative in the harm reduction strategy for adult smokers unable to quit. Using a systems toxicology approach, we investigated and compared the exposure eff...
ORGANISM(S): Homo sapiens 
2017-04-01 | E-MTAB-5608 | biostudies-arrayexpress
TranscriptomicsTranscriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury
Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multice...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-57387 | biostudies-arrayexpress
MetabolomicsMultiomic profiling of iron-deficient infant monkeys reveals alterations in neurologically important biochemicals in serum and cerebrospinal fluid before the onset of anemia

The effects of iron deficiency (ID) during infancy extend beyond the hematologic compartment and include short- and long-term adverse effects on many tissues including the brain. However, sensitive biomarkers of iron-dependent brain health are lacking in humans. To determine whether serum and cer...

2022-07-12 | MTBLS3388 | MetaboLights
TranscriptomicsDeciphering myeloma risk loci by eQTL analysis
Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) at 7 loci influencing multiple myeloma (MM) risk. We generated expression quantitative trait loci (eQTL) data on malignant plasma cells from two patient series (totaling 848) to fine map the risk loci assoc...
ORGANISM(S): Homo sapiens 
2014-12-09 | E-MTAB-2299 | biostudies-arrayexpress
UnknownA peptide-spectrum scoring system based on ion alignment, intensity, and pair probabilities.
Not available
S-EPMC4117239 | biostudies-literature
UnknownKIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation.
Not available
S-EPMC5501362 | biostudies-literature
TranscriptomicsHigh VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia.
High VEGFC mRNA expression of AML blasts is related to increased in vitro and in vivo drug resistance. The prognostic significance of VEGFC on long-term outcome and its associated gene expression profiles remain to be defined. We studied the effect of VEGFC on treatment outcome and investigated gene...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22056 | biostudies-arrayexpress
UnknownOutcomes among North American patients with diffuse large B-cell lymphoma are independent of tumor Epstein-Barr virus positivity or immunosuppression.
Not available
S-EPMC5792274 | biostudies-literature
TranscriptomicsFunctional enhancers at the gene-poor 8q24 cancer-linked locus
Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we profiled a 5-megabase chromatin segment encompassin...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-19561 | biostudies-arrayexpress
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